Results 151 to 160 of about 2,540 (202)
Bupivacaine Versus Liposomal Bupivacaine For Pain Control
Drug Research, 2017 AbstractLocal infiltrations and regional blocks have been some of the effective ways employed to manage and control post-operative pain. One of the limitations of administration of local anesthesia drugs in post-operative conditions is its inability to act for a longer period of time.
Siavash, Beiranvand +1 more
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Liposomal Bupivacaine in Forefoot Surgery
Foot and Ankle International, 2015Background: Liposomal bupivacaine is increasingly being utilized in attempts to provide prolonged local analgesia in the immediate postoperative period. The purpose of this study was to quantify the reduction in opioid consumption as well as postoperative pain scores in the postoperative period when liposomal ...
Cynthia L Green
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Expert Opinion on Pharmacotherapy, 2014
Although generally considered both safe and effective, local anesthetics are often used in conjunction with opioids postoperatively in part because of the limited duration of drug action of local anesthetics. Much interest exists in extending the duration of local anesthetics' effects, which may reduce the requirement for opioid pain medications that ...
Aaron, Skolnik, Tong J, Gan
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Although generally considered both safe and effective, local anesthetics are often used in conjunction with opioids postoperatively in part because of the limited duration of drug action of local anesthetics. Much interest exists in extending the duration of local anesthetics' effects, which may reduce the requirement for opioid pain medications that ...
Aaron, Skolnik, Tong J, Gan
exaly +3 more sources
Liposomal bupivacaine and clinical outcomes
Best Practice & Research Clinical Anaesthesiology, 2014In the multimodal approach to the management of postoperative pain, local infiltration and regional blocks have been increasingly utilized for pain control. One of the limitations of local anesthetics in the postoperative setting is its relatively short duration of action.
Yi Cai Isaac, Tong +2 more
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Bupivacaine Binding to Pegylated Liposomes
Anesthesia & Analgesia, 2009Local anesthetic drugs, such as bupivacaine, can cause severe toxicity. Lipid emulsions have been proposed and used clinically for treating such cases. Liposomes may be an alternative for overdose treatment because of their unique structures and surface charges, which allows them to act as high affinity drug "sinks" and remove bupivacaine from solution.
Brett A, Howell, Anuj, Chauhan
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Liposomal bupivacaine for regional anesthesia
Current Opinion in Anaesthesiology, 2015Using a regional block in a multimodal approach to postoperative analgesia management involves addressing, which local anesthetic and how much should be used to ensure adequate pain relief to reduce related morbidity and mortality. This article will review literature surrounding the recently approved formulation of slow release liposomal bupivacaine ...
Anna, Uskova, Jessica E, O'Connor
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Characterization of exparel bupivacaine multivesicular liposomes
International Journal of Pharmaceutics, 2023Exparel is a bupivacaine multivesicular liposomes (MVLs) formulation developed based on the DepoFoam technology. The complex composition and the unique structure of MVLs pose challenges to the development and assessment of generic versions. In the present work, we developed a panel of analytical methods to characterize Exparel with respect to particle ...
Minzhi Yu +7 more
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Liposomal Bupivacaine Versus Immediate-Release Bupivacaine for Postoperative Pain Control
Annals of Pharmacotherapy, 2021Background Liposomal bupivacaine (LB) is increasingly being used for postoperative pain control, but there are conflicting efficacy data when compared with immediate-release bupivacaine (IRB). Objective To evaluate the comparative ...
Atul Dilawri, Marcia Wyman, Sneha Shah
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Randomized Trial of Bupivacaine Versus Liposomal Bupivacaine in Minimally Invasive Lobectomy
The Annals of Thoracic Surgery, 2022The objective of this single-blind randomized study is to compare local infiltration of bupivacaine or liposomal bupivacaine (LipoB) in narcotic naïve patients undergoing minimally invasive lobectomy for early stage lung cancer.Adult patients without previous lung surgery undergoing minimally invasive lobectomy (robotic or thoracoscopic) for early ...
Sowmyanarayanan, Thuppal +7 more
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