Results 91 to 100 of about 326,077 (343)

OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation [PDF]

, 2010
The dynamin-related GTPase OPA1 is mutated in autosomal dominant optic atrophy (DOA) (Kjer type), an inherited neuropathy of the retinal ganglion cells.
Alexander, Amati-Bonneau, Ardail, David C. Chan, Delettre, Delettre, Detmer, DeVay, Frezza, Griparic, Herlan, Heymann, Hudson, Ingerman, Jenny E. Hinshaw, Jürgen A.W. Heymann, Leonard, Meeusen, Olichon, Praefcke, Pucadyil, Rujiviphat, Sesaki, Song, Song, Tadato Ban, Tondera, Zhiyin Song, Zick   +28 more
core   +3 more sources

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

In vitro conversion of squalene from squalene-phospholipid liposomes into sterols by rat liver microsomes and cytosol

Journal of Lipid Research, 1980
When rat liver cytosol, possessing sterol carrier protein (SCP) activity was incubated with [3H]-squalene-phospholipid liposomes, cofactors, and rat liver microsomes, squalene from the liposomes was converted into sterols.
R J Morin, M V Srikantaiah
doaj   +1 more source

Layer-By-Layer Assembly of Graphene Oxide on Thermosensitive Liposomes for Photo-Chemotherapy [PDF]

, 2018
Stimuli responsive polyelectrolyte nanoparticles have been developed for chemo-photothermal destruction of breast cancer cells. This novel system, called layer by layer Lipo-graph (LBL Lipo-graph), is composed of alternate layers of graphene oxide (GO ...
Hashemi, Mohadeseh, Herpin, Matthew J., Milner, Thomas E., Mohagheghi, Mohammad Ali, Mohammadi, Javad, Muralidharan, Bharadwaj, Omidi, Meisam, Smyth, Hugh D.C., Tayebi, Lobat   +8 more
core   +1 more source

Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems.

ACS Nano, 2018
Extracellular vesicles (EVs) are recognized as nature's own carriers to transport macromolecules throughout the body. Hijacking this endogenous communication system represents an attractive strategy for advanced drug delivery.
M. Piffoux, A. Silva, C. Wilhelm, F. Gazeau, D. Tareste   +4 more
semanticscholar   +1 more source

Mapping Nanoscale Protein‐Corona Kinetics of DoE‐Optimized Perfluorocarbon Encapsulated‐PLGA Nanoparticles by In Situ, Time‐Resolved Synchrotron SAXS

Advanced Healthcare Materials, EarlyView.
A two‐phase workflow (OFAT screening followed by central composite design) maps how processing variables tune PFCE‐PLGA nanoparticle size, dispersity, surface charge, loading, and 19F‐MRI signal. In situ, time‐resolved synchrotron SAXS tracks albumin‐corona growth on intact dispersions and reveals PFCE‐dependent adsorption pathways.
Joice Maria Joseph, Maria Rosa Gigliobianco, Cristina Minnelli, Paolo Moretti, Francesco Spinozzi, Giovanna Mobbili, Sara Pistolesi, Cristina Casadidio, Gabriella Teti, Roberta Censi, Stefano Antonio Gattone, Piera Di Martino   +11 more
wiley   +1 more source

Design of hybrid gels based on gellan-cholesterol derivative and P90G liposomes for drug depot applications [PDF]

, 2017
Gels are extensively studied in the drug delivery field because of their potential benefits in therapeutics. Depot gel systems fall in this area, and the interest in their development has been focused on long-lasting, biocompatible, and resorbable ...
Cencetti, Claudia, DI MEO, Chiara, Manca, Maria Letizia, Manconi, Maria, Matricardi, Pietro, Montanari, Elita, Palmieri, Francesca Romana, Zoratto, Nicole   +7 more
core   +2 more sources

Interplay of protein corona and immune cells controls blood residency of liposomes

Nature Communications, 2019
In vivo liposomes, like other types of nanoparticles, acquire a totally new ‘biological identity’ due to the formation of a biomolecular coating known as the protein corona that depends on and modifies the liposomes’ synthetic identity.
Francesca Giulimondi, L. Digiacomo, D. Pozzi, S. Palchetti, E. Vulpis, A. Capriotti, R. Chiozzi, A. Laganà, H. Amenitsch, L. Masuelli, G. Peruzzi, M. Mahmoudi, I. Screpanti, A. Zingoni, G. Caracciolo   +14 more
semanticscholar   +1 more source

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Liposomes containing dexamethasone: preparation, characteristics and application in ophthalmology

Тонкие химические технологии, 2011
Glucocorticoid dexamethasone (DM) liposomes of various lipid compositions were obtained. DM was used in insoluble form and in water-soluble form as disodium salt of dexamethasone phosphate (DMP).
N. L. Leparskаya, G. M. Sоrokoumоva, Yu. V. Sycheva, I. P. Horoshilovа-Maslova, A. P. Kaplun, I. I. Kereev, R. A. Gundorova, V. V. Neroev, V. I. Shvets   +8 more
doaj