Results 101 to 110 of about 4,073 (218)

Lipoic acid protein ligases in Plasmodium spp. [PDF]

, 2008
Protozoan parasites of the genus Plasmodium are the causative agent of malaria. The four human pathogenic species infect more than 500 million people each year, causing the death of at least 1 million people.
Günther, Svenja
core   +1 more source

Mitochondria as Regulators of Nonapoptotic Cell Death in Cancer

MedComm, Volume 6, Issue 8, August 2025.
Mitochondrial fission and fusion are key processes in maintaining cellular health. Fission is driven by proteins like, Fis‐1, which recruits DRP‐1, to facilitate the division of mitochondria. Fusion, however, is mediated by mitofusion 1(MFN1), mitofusion 2(MFN2), and optic atrophy 1 (OPA1), which work together to merge mitochondria, allowing functional
Saloni Malla, Rabin Neupane, Saloni Sood, Noor Hussein, Mariam Abou‐Dahech, David Terrero, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +8 more
wiley   +1 more source

Crosstalk Between Ferroptosis and Cuproptosis in Intervertebral Disc Degeneration: Mechanisms, Therapeutic Targets, and Future Directions

JOR SPINE, Volume 8, Issue 2, June 2025.
GSH, oxidative stress, TCA cycle, autophagy, and copper are the intersection targets of ferroptosis and cuproptosis in IVDD. ABSTRACT Background Intervertebral disc degeneration (IVDD) is a prevalent degenerative disease, with low back pain as its primary clinical symptom, imposing significant burdens on individuals and society.
Zhongpan Li, Liangwei Wang, Xiaojun Wu, Rui Huang, Yi Yuan   +4 more
wiley   +1 more source

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming

Advanced Science, Volume 12, Issue 20, May 29, 2025.
Spatially resolved multiomics reveals that high‐copper zones are closely associated with tumor metastasis, immune‐desert phenotypes, and oxidative‐phosphorylation (OXPHOS)‐dependent proliferation. A targeted bacterial nanovesicle delivering copper‐depleting agents effectively reduces tumor copper levels, inhibits OXPHOS‐dependent tumor growth, and ...
Lin Chen, Saibo Ma, Hao Wu, Lingna Zheng, Yunpeng Yi, Guangnian Liu, Baoyi Li, Jiayi Sun, Yang Du, Bing Wang, Yike Liu, Cheng Zhang, Jing Chang, Yuheng Pang, Wenjing Wang, Meng Wang, Motao Zhu   +16 more
wiley   +1 more source

Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice [PDF]

, 2019
There has been a growing interest toward mitochondrial fatty acid synthesis (mtFAS) since the recent discovery of a neurodegenerative human disorder termed MEPAN (mitochondrial enoyl reductase protein associated neurodegeneration), which is caused by ...
Autio, Kaija J., Hiltunen, J. Kalervo, Jokivarsi, Kimmo, Kastaniotis, Alexander J., Koivisto, Henna, Manninen, Aki, Miinalainen, Ilkka J., Nair, Remya R., Poutiainen, Pekka, Tanila, Heikki   +9 more
core   +1 more source

Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex [PDF]

, 2007
The human pyruvate dehydrogenase multi-enzyme complex (PDC) catalyses the oxidative decarboxylation of pyruvate, transferring the resultant acetyl group to coenzyme A.
Al-Amodi, Hiba Saeed Bagader
core   +1 more source

LplA1-dependent utilization of host lipoyl peptides enables Listeria cytosolic growth and virulence [PDF]

, 2007
The bacterial pathogen Listeria monocytogenes replicates within the cytosol of mammalian cells. Mechanisms by which the bacterium exploits the host cytosolic environment for essential nutrients are poorly defined. L.
Bast A., Freitag N.E., Horton R.M., Konishi T., Marquis H., Morris T.W., Portnoy D.A., Welshimer H.J.   +7 more
core   +1 more source

Lipoyltransferase 1 Gene Defect Resulting in Fatal Lactic Acidosis in Two Siblings

Case Reports in Obstetrics and Gynecology, 2016
A term male neonate developed severe intractable lactic acidosis on day of life 1 and died the same day at our institution. The family previously lost another term, female newborn on day of life 1 from suspected sepsis at an outside hospital.
Véronique Taché, Liga Bivina, Sophie White, Jeffrey Gregg, Joshua Deignan, Simeon A. Boyadjievd, Francis R. Poulain   +6 more
doaj   +1 more source

Acute Loss of Iron-Sulfur Clusters Results in Metabolic Reprogramming and Generation of Lipid Droplets in Mammalian Cells [PDF]

, 2018
Iron–sulfur (Fe-S) clusters are ancient cofactors in cells and participate in diverse biochemical functions, including electron transfer and enzymatic catalysis.
Crooks, Daniel R., Fan, Teresa Whei-Mei, Haller, Ronald G., Higashi, Richard M., Jarnik, Michal, Lane, Andrew N., Linehan, W. Marston, Maio, Nunziata, Rouault, Tracey A., Yang, Ye   +9 more
core   +2 more sources

Copper-induced cell death mechanisms and their role in the tumor microenvironment

Frontiers in Cell Death
Copper is an essential cofactor for all organisms. However, it can become toxic if its concentration rises above a specific level. This level is controlled by evolutionary conserved homeostatic mechanisms.
Yujuan Jiao, Hongxin Wang, Meng Zhu, Tengteng Liu, Yuqi Li, Shuo Yang, Minghui Zhang, Lei Zhang   +7 more
doaj   +1 more source