Results 101 to 110 of about 4,273 (194)
CellsCuproptosis is a novel cell death dependent on mitochondrial respiration and regulated by copper. While the study of it is mainly focused on tumor therapy, in the present study, two key cuproptosis-related genes, ferredoxin (FDX1) and dihydrolipoamide S ...
Yuxin Zhang +4 more
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The 3-hydroxyacyl-ACP dehydratase component of the plant mitochondrial fatty acid synthase system [PDF]
, 2017 We report the characterization of the Arabidopsis 3-hydroxyacyl-acyl carrier protein (ACP) dehydratase (mtHD) component of the mitochondrial fatty acid synthase (mtFAS) system, encoded by AT5G60335. The mitochondrial localization and catalytic capability
Guan, Xin +11 more
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Investigating the chemistry of lipoyl synthase
, 2008 The radical SAM protein lipoyl synthase (LipA) is essential for lipoic acid biosynthesis via sulfur insertions into the unactivated C6 and C8 centres of a protein-bound octanoyl group. Using an in vitro assay which makes use of a small peptide mimic of the protein substrate, it has now been shown at which carbon centre sulfur insertion first occurs ...
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Ferredoxin 1 is essential for embryonic development and lipid homeostasis
eLifeMammalian ferredoxin 1 and 2 (FDX1/2) belong to an evolutionary conserved family of iron-sulfur cluster containing proteins and act as electron shutters between ferredoxin reductase (FDXR) and numerous proteins involved in critical biological pathways ...
Shakur Mohibi +5 more
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Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension. [PDF]
Impaired pulmonary angiogenesis plays a pivotal role in the progression of pulmonary arterial hypertension (PAH) and patient mortality, yet the molecular mechanisms driving this process remain enigmatic.
Baggett, Brenda +11 more
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Research progress on the regulation of cuproptosis-related genes by non-coding RNAs in tumors
OncologieCuproptosis represents a mechanistically distinct programmed cell death pathway divergent from canonical apoptosis, necrosis, and ferroptosis. This copper-dependent process critically modulates tumorigenesis, malignant progression, and clinical outcomes ...
Du Yuxin +4 more
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Studying the Lipoyl Synthase mediated conversion of Octanoyl substrates to Lipoyl products
, 2013 a-Lipoic acid is a cofactor used during oxidative metabolism reactions by several enzymes, including branched chain keto acid dehydrogenases, the glycine cleavage system, pyruvate dehydrogenase and a-ketoglutarate dehydrogenase. The lipoic acid is attached to the e-amino group of a specific lysine residue via an amide bond and acts as a carrier of acyl
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Nature CommunicationsProteins with chemically regulatable phase separation are of great interest in the fields of biomolecular condensates and synthetic biology. Intrinsically disordered proteins (IDPs) are the dominating building blocks of biomolecular condensates which ...
Jinglei Nie +9 more
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Communications BiologyCuproptosis, a copper-triggered cell death pathway, holds therapeutic potential for cancers, but its regulatory mechanisms in hepatocellular carcinoma (HCC) remain undefined.
Chutian Wu +10 more
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