Results 201 to 210 of about 4,073 (218)
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Lipoylated Peptides and Proteins
2015Lipoic acid is a heterocyclic sulfur-containing derivative of octanoic acid that is characterized by a 1,2-dithiolane ring. Found in nature as an essential protein cofactor, lipoic acid is implicated in cellular metabolic reactions. In particular, lipoylation is an essential posttranslational modification involved in cellular energetic metabolism ...
Rentier, Cédric +4 more
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Studies on the reaction mechanism of lipoyl dehydrogenase
Biochimica et Biophysica Acta, 1961Abstract A comparison of the rates of reaction of lipoyl dehydrogenase with dihydrolipoamide, reduced diphosphopyridine nucleotide and oxidized acetyl pyridine diphosphopyridine nucleotide have shown the involvement of the enzyme flavin in the transhydrogenase reaction catalyzed by this enzyme.
C. Veeger, V. Massey
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Multiplicity and Origin of Isoenzymes of Lipoyl Dehydrogenase
European Journal of Biochemistry, 1972Reports in the literature on the number of isoenzymes of lipoyl dehydrogenase in mammalian heart mitochondria vary from 2 to 13 and one report claims that no isoenzymes occur in vivo. The present paper provides evidence that 6 main isoenzymes and 2 minor ones of lipoyl dehydrogenase occur in beef and pig heart, 3 of the main components being associated
William C. Kenney +3 more
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Determination and properties of erythrocyte lipoyl dehydrogenase
Mikrochimica Acta, 1975Erythrocyte lipoyl dehydrogenase activity has been determined using the Pd(II)-1,3-bis(2′-pyridyl)1,2-diaza-prop-2-ene colorimetric method. Properties of the red cell enzyme are described and normal values for erythrocyte lipoyl dehydrogenase are given. The possible role of this enzyme in the erythrocytes is discussed.
A M Seet, K T Lee
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Synthesis and Tribological Investigation of Lipoyl Glycerides
Journal of Agricultural and Food Chemistry, 2014Lipoyl glycerides were synthesized by enzymatic transesterification of lipoic acid with high-oleic sunflower oil in 2-methyl-2-butanol solvent. The synthesis gave a crude product mixture comprising unreacted lipoic acid, free fatty acids, and several lipoyl glyceride structures of varying lipoic acid substitution.
David L. Compton +4 more
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1996
Lipoic acid is a prosthetic group of the acyltransferase (E2) components of the pyruvate, (α-ketoglutarate, and branched chain α-keto acid dehydrogenase complexes, X component (the dihydrolipoamide dehydrogenase-binding protein) of the eucaryotic pyruvate dehydrogenase complex, and H-protein of the glycine cleavage system. The lipoyl moiety is attached
K. Okamura-Ikeda +2 more
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Lipoic acid is a prosthetic group of the acyltransferase (E2) components of the pyruvate, (α-ketoglutarate, and branched chain α-keto acid dehydrogenase complexes, X component (the dihydrolipoamide dehydrogenase-binding protein) of the eucaryotic pyruvate dehydrogenase complex, and H-protein of the glycine cleavage system. The lipoyl moiety is attached
K. Okamura-Ikeda +2 more
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Characterization of a Radical Intermediate in Lipoyl Cofactor Biosynthesis
Journal of the American Chemical Society, 2015Lipoyl synthase (LipA) catalyzes the final step in the biosynthesis of the lipoyl cofactor, the insertion of two sulfur atoms at C6 and C8 of an n-octanoyl chain. LipA is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes and uses two [4Fe-4S] clusters to catalyze its transformation.
Alexey Silakov +6 more
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Plant Physiology and Biochemistry, 2020
Lipoic acid (LA) and its reduced form (dihydrolipoic acid, DHLA) have unique antioxidant properties among such molecules. Moreover, after a process termed lipoylation, LA is an essential prosthetic group covalently-attached to several key multi-subunit enzymatic complexes involved in primary metabolism, including E2 subunits of pyruvate dehydrogenase ...
Araya Flores, Jorge +4 more
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Lipoic acid (LA) and its reduced form (dihydrolipoic acid, DHLA) have unique antioxidant properties among such molecules. Moreover, after a process termed lipoylation, LA is an essential prosthetic group covalently-attached to several key multi-subunit enzymatic complexes involved in primary metabolism, including E2 subunits of pyruvate dehydrogenase ...
Araya Flores, Jorge +4 more
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Protein lipoylation: mitochondria, cuproptosis, and beyond
Trends in Biochemical SciencesProtein lipoylation, a crucial post-translational modification (PTM), plays a pivotal role in mitochondrial function and emerges as a key player in cell death through cuproptosis. This novel copper-driven cell death pathway is activated by excessive copper ions binding to lipoylated mitochondrial proteins, disrupting energy production and causing ...
Cheng-Han Lin +5 more
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Journal of Chromatography B: Biomedical Sciences and Applications, 1996
An HPLC lipoamidase (lipoyl-X hydrolase) assay method has been developed, which uses a novel fluorescent substrate, lipoyl-6-aminoquinoline (LAQ). LAQ is synthesized from lipoic acid and 6-aminoquinoline (AQ) through lipoyl chloride as an intermediate and is conveniently purified by washing with chloroform-methanol.
Toshiaki Tanaka +5 more
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An HPLC lipoamidase (lipoyl-X hydrolase) assay method has been developed, which uses a novel fluorescent substrate, lipoyl-6-aminoquinoline (LAQ). LAQ is synthesized from lipoic acid and 6-aminoquinoline (AQ) through lipoyl chloride as an intermediate and is conveniently purified by washing with chloroform-methanol.
Toshiaki Tanaka +5 more
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