Results 211 to 218 of about 4,073 (218)
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Plant Biology, 2013
AbstractOctanoyltransferases (LIP2) are important for the lipoylation of several α‐ketoacid decarboxylases and glycine decarboxylase, all of which are essential multienzyme complexes of central metabolism, by attaching de novo‐synthesised octanoyl moieties to the respective target subunits.
Ekkehard Neuhaus +3 more
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AbstractOctanoyltransferases (LIP2) are important for the lipoylation of several α‐ketoacid decarboxylases and glycine decarboxylase, all of which are essential multienzyme complexes of central metabolism, by attaching de novo‐synthesised octanoyl moieties to the respective target subunits.
Ekkehard Neuhaus +3 more
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[31] Lipoyl disulfide reducing polymers
1979Publisher Summary This chapter describes the preparation of thiolated polymers capable of reducing S–S bonds. They are easily synthesized by the covalent attachment of lipoic acid to different insoluble matrices, such as Sephadex, Sepharose, cellulose, polyacrylamide, and polystyrene.
Marian Gorecki, Abraham Patchornik
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[32] Assay for protein lipoylation reaction
1995Publisher Summary This chapter discusses the assay for protein lipoylation reaction. Lipoate attaches to the ɛ -amino group of the specific lysine residue of the proteins via an amide linkage. The lipoyllysine residue functions as a carrier of intermediates of the reactions and reducing equivalents between the active sites of the components of the ...
Kazuko Fujiwara +2 more
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Characterization of Lipoyl Synthase from Mycobacterium tuberculosis
Biochemistry, 2016The prevalence of multiple and extensively drug-resistant strains of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is on the rise, necessitating the identification of new targets to combat an organism that has infected one-third of the world's population, according to the World Health Organization.
Maria-Eirini Pandelia +6 more
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Crystal Structure of Bovine Lipoyltransferase in Complex with Lipoyl-AMP
Journal of Molecular Biology, 2007Lipoic acid is an essential cofactor of the alpha-ketoacid dehydrogenase complexes and the glycine cleavage system. It is covalently attached to a specific lysine residue of the subunit of the complexes. The bovine lipoyltransferase (bLT) catalyzes the lipoic acid attachment reaction using lipoyl-AMP as a substrate, forming a lipoylated protein and AMP.
Kazuko Fujiwara +7 more
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The role of lipoylation in mitochondrial adaptation to methionine restriction
BioEssaysAbstractDietary methionine restriction (MR) is associated with a spectrum of health‐promoting benefits. Being conducive to prevention of chronic diseases and extension of life span, MR can activate integrated responses at metabolic, transcriptional, and physiological levels.
Jingyuan Xue, Cunqi Ye
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On the reaction mechanism of lipoyl dehydrogenase
Biochimica et Biophysica Acta, 1960C. Veeger, V. Massey
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[35] Asparagusate dehydrogenase and lipoyl dehydrogenase from asparagus
1979Publisher Summary Asparagusate dehydrogenase and lipoyl dehydrogenase are essential components of asparagus pyruvate dehydrogenase complexes, which catalyze a CoA- and NAD-linked oxidative decarboxylation of pyruvate. These two enzymes are flavoproteins and catalyze the oxidoreduction of asparagusate and lipoate. Asparagusate dehydrogenase and lipoyl
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