Results 111 to 120 of about 659,295 (264)

Modelling of Andrographolide Extraction from Andrographis Paniculata Leaves in a Soxhlet Extractor [PDF]

, 2006
Andrographolide is the main diterpenoid lactone contained in the leaves of Andrographis paniculata. This bioactive component has multifunctional medicinal properties such as activity against fever, dysentery, diarrhoea, inflammation, and sore throat as
Kumoro, A.C., Hasan, Masitah, Hasan, M., Kumoro, A. C.   +3 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Molecular dynamics simulation of boric acid extraction by isobutanol/isooctanol liquid-liquid extraction

Chemical Engineering Journal Advances
Boric acid, a vital chemical in industries, agriculture, and high-tech fields, is primarily extracted from Salt Lake brines via liquid-liquid extraction. The efficiency differences between alcohols remain unclear.
Jisheng Li, Xu Zhao, Yuheng Fan, Changyu Sun, Yufeng Hu, Laiyong Zhang, Fayan Zhu, Jilong Han   +7 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

OPTIMALISASI EKSTRAKSI DAN UJI STABILITAS PHYCOCYANIN DARI MIKROALGA Spirulina platensis

Teknik, 2012
The growing awareness of the importance of natural colours especially food and cosmetic colorants has placedgreat demand on biological sources of natural colours.
Bakti Jos, Prayudi Eko Setyawan, Yudha Satria   +2 more
doaj  

Autonomous Control and Dynamics Simulation of a 3-Stages Countercurrent Liquid-Liquid Extraction: Trimetozine Purification as a Case Study

, 2019
Liquid-liquid extraction is a technique of extraction heavily used in chemical industry and especially for purification of pharmaceuticals. Trimetozine was used as a case study to test the performance of an implemented platform capable of conducting the ...
Brahim, Benyahia, Ian, Houson, Nazer, Rajoub, Zied, Hosni, Alastair, Florence, Alison, Nordon   +5 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

LIQUID-LIQUID EQUILIBRIUM AND KINETICS OF ETHANOLIC EXTRACTION OF SOYBEAN OIL USING ETHYL ACETATE AS CO-SOLVENT

, 2018
This work reports a new set of experimental data for the liquid-liquid equilibrium (LLE) of the system (soybean oil + ethyl acetate + anhydrous ethanol) and the kinetics of crude oil extraction from soybean flakes using anhydrous ethanol + ethyl acetate ...
João L. A. Dagostin (5838161), Danielle Carpiné (5838164), Paulo R. S. dos Santos (5838167), Marcos L. Corazza (5838170)   +3 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source