Results 231 to 240 of about 254,930 (339)

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Photo-Triggered Charge Control Induces Dissociation of Complex Coacervates. [PDF]

Polymers (Basel)
Kakitani R, Nishimura T, Vu TN, Kizaki C, Yusa SI.   +4 more
europepmc   +1 more source

NMR microscopy with a high-resolution liquid-state spectroscopy probe

Concepts in Magnetic Resonance Part B: Magnetic Resonance Engineering, 2005
Sylvain Miraux, Gérard Raffard, Laurent Pothuaud, Laure De Taillac, Joelle Amédée, Paul Canioni, Eric Thiaudière, Jean-Michel Franconi   +7 more
openaire   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Oppositely-charged coordination cages form a type I porous ionic liquid with two pore sizes.

Mater Horiz
Adorinni S, Ryan HP, Ma L, Ronson TK, Gaikwad S, Rossi B, Nasi L, Nitschke JR, Marchesan S.   +8 more
europepmc   +1 more source

Room-Temperature Framework Oxygen Isotope Exchange during Interaction of Water with Hydrophilic Pure-Silica Zeolites Studied Using Nuclear Magnetic resonance Spectroscopy and Neutron Diffraction. [PDF]

J Am Chem Soc
Kelly NL, Stanzione MG, Brako-Amoafo D, Lawrence GB, Rice CM, Wheatley PS, Keys JM, Heard CJ, Fischer HE, Gibbs AS, Ashbrook SE, Morris RE.   +11 more
europepmc   +1 more source

Metabolomic approach in the study of foods by high-resolution liquid state NMR and HPLC techniques

, 2022
DI MATTEO, GIACOMO
openalex   +1 more source

DOTA‐grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance‐reversal Agents (MRRAs) Combating Against New Delhi Metallo‐β‐lactamase (NDM)‐producing Bacteria

Advanced Science, EarlyView.
Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Ruixue Wang, Jian Zhang, Yun li, Liping Qiao, Zhuorui Dong, Dandan Cui, Peirong Bai, Liping Li, Bing Cao, Ruiping Zhang   +9 more
wiley   +1 more source

Combined Experimental and Computational Study on the Structure-Property Relationships of Mono- and Dicationic Imidazolium Ionic Liquids for CO₂ Capture. [PDF]

J Phys Chem B
Duarte E, Forneck V, Motta E, Dos Santos L, Andreeva NA, Chaban VV, Bernard FL, Einloft S.   +7 more
europepmc   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source