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Pathologists and liquid biopsies: to be or not to be?
Virchows Archiv, 2016Recently, the advent of therapies targeting genomic alterations has improved the care of patients with certain types of cancer. While molecular targets were initially detected in nucleic acid samples extracted from tumor tissue, detection of nucleic acids in circulating blood has allowed the development of what has become known as liquid biopsies ...
Helmut Popper, Paul Hofman
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Liquid Biopsy Based on Cell-Free DNA and RNA.
Annual Review of Biomedical EngineeringThis review delves into the rapidly evolving landscape of liquid biopsy technologies based on cell-free DNA (cfDNA) and cell-free RNA (cfRNA) and their increasingly prominent role in precision medicine.
C. Loy +3 more
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Acta Cytologica, 2018
The identification of non-small cell lung cancer (NSCLC) patients potentially responsive to targeted therapies relies on a number of relevant biomarkers, including <i>EGFR</i>, <i>ALK</i>, <i>ROS-1,</i> and PD-L1. Biomarker identification is most commonly based on surgical sample collection. However, when tissues are
Pisapia, Pasquale +2 more
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The identification of non-small cell lung cancer (NSCLC) patients potentially responsive to targeted therapies relies on a number of relevant biomarkers, including <i>EGFR</i>, <i>ALK</i>, <i>ROS-1,</i> and PD-L1. Biomarker identification is most commonly based on surgical sample collection. However, when tissues are
Pisapia, Pasquale +2 more
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The Cancer Journal, 2018
No two tumors are the same, and even within a single patient, the intratumor heterogeneity that exists contributes to the overall complexity in disease treatment and management. Yet, tumors are constantly shedding fragments into circulation with genetic material that help to fingerprint the tumor of origin.
Rhonda M. Jack, Sunitha Nagrath
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No two tumors are the same, and even within a single patient, the intratumor heterogeneity that exists contributes to the overall complexity in disease treatment and management. Yet, tumors are constantly shedding fragments into circulation with genetic material that help to fingerprint the tumor of origin.
Rhonda M. Jack, Sunitha Nagrath
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Journal of biological regulators and homeostatic agents, 2019
During the early formation and growth of primary tumor (e.g., breast, colon, or prostate cancer), cells are shed from the primary tumor and then circulate through the bloodstream. Many of the major recent advances in targeted therapies have relied on the acquisition of tumor tissue via biopsy before initiation of therapy or after the onset of ...
Candotto, V +5 more
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During the early formation and growth of primary tumor (e.g., breast, colon, or prostate cancer), cells are shed from the primary tumor and then circulate through the bloodstream. Many of the major recent advances in targeted therapies have relied on the acquisition of tumor tissue via biopsy before initiation of therapy or after the onset of ...
Candotto, V +5 more
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Liquid Biopsy: General Concepts
Acta Cytologica, 2019Liquid biopsy provides the opportunity of detecting, analyzing and monitoring cancer in various body effluents such as blood or urine instead of a fragment of cancer tissue. It is composed of different biological matrices such as circulating tumor cells (CTCs), cell free nucleic acids, exosomes or tumors “educated platelets.” In addition to ...
Poulet, Geoffroy +2 more
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Image-Guided Biopsy/Liquid Biopsy
2020Direct tissue sampling is a critical element of cancer care, essential for confirming diagnosis, tumor histology, and staging. Image-guided percutaneous biopsy is the most commonly used technique to procure tumor tissue. Advances in needle design, tissue sampling techniques, and imaging technology have improved the safety and yield of image-guided ...
Rene Roberts +3 more
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2022
New studies are mainly focused on the new, minimally invasive biomarkers presenting in body fluids as the real-time representative of tumors, entitled “liquid biopsy.” Liquid biopsy contains tumor-derived cells, nucleic acids (DNA, RNA), and tumor vesicles that represent the tumor characteristics.
Aghamir S. M. K. +4 more
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New studies are mainly focused on the new, minimally invasive biomarkers presenting in body fluids as the real-time representative of tumors, entitled “liquid biopsy.” Liquid biopsy contains tumor-derived cells, nucleic acids (DNA, RNA), and tumor vesicles that represent the tumor characteristics.
Aghamir S. M. K. +4 more
openaire +2 more sources
Science, 2021
Medicine Liquid biopsies, analyses of cell-free DNA that circulates in the blood, can be used in prenatal testing, oncology, and to monitor organ transplant recipients. Lo et al. review the nongenetic information that can be gleaned from analyses of cell-free DNA, which offers additional promise for the applications of this procedure.
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Medicine Liquid biopsies, analyses of cell-free DNA that circulates in the blood, can be used in prenatal testing, oncology, and to monitor organ transplant recipients. Lo et al. review the nongenetic information that can be gleaned from analyses of cell-free DNA, which offers additional promise for the applications of this procedure.
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Liquid biopsy in ovarian cancer
Clinica Chimica Acta, 2020Ovarian cancer is typically diagnosed at an advanced stage and poses a significant challenge to treatment and recovery. Relapsed ovarian cancer and chemoresistance of ovarian tumor cells are other clinical challenges. Liquid biopsy is an essential non-invasive diagnostic test that evaluates circulating tumor cells and tumor DNA, as well as other blood ...
Boddapati Kalyani Bhardwaj +3 more
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