Results 11 to 20 of about 607,507 (319)

Comprehensive metabolic profiling of Parkinson’s disease by liquid chromatography-mass spectrometry

Molecular Neurodegeneration, 2021
Background Parkinson’s disease (PD) is a prevalent neurological disease in the elderly with increasing morbidity and mortality. Despite enormous efforts, rapid and accurate diagnosis of PD is still compromised.
Y. Shao, Tianbai Li, Zheyi Liu, Xiaolin Wang, Xiaojiao Xu, Song Li, Guowang Xu, W. Le   +7 more
semanticscholar   +1 more source

Overview of Recent Liquid Chromatography Mass Spectrometry-Based Methods for Natural Toxins Detection in Food Products

Toxins, 2022
Natural toxins include a wide range of toxic metabolites also occurring in food and products, thus representing a risk for consumer health. In the last few decades, several robust and sensitive analytical methods able to determine their occurrence in ...
A. De Girolamo, V. Lippolis, M. Pascale
semanticscholar   +1 more source

Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2015
This study describes the investigation of degradation products of donepezil (DP) using stability indicating RP-HPLC method for determination of donepezil, which is a centrally acting reversible acetylcholinesterase inhibitor.
Mladenović Aleksandar R., Jadranin Milka B., Pavlović Aleksandar D., Petrović Slobodan D., Drmanić Saša Ž., Avramov-Ivić Milk L., Mijin Dušan Ž.   +6 more
doaj   +1 more source

Characterization of volatile thiols in Chinese liquor (Baijiu) by ultraperformance liquid chromatography–mass spectrometry and ultraperformance liquid chromatography–quadrupole-time-of-flight mass spectrometry

Frontiers in Nutrition, 2022
Volatile thiols give a unique flavor to foods and they have been extensively studied due to their effects on sensory properties. The analytical assay of volatile thiols in food is hindered by the complexity of the matrix, and by both their high ...
Yan Yan, Yan Yan, Jun Lu, Yao Nie, Changwen Li, Shuang Chen, Yan Xu   +6 more
doaj   +1 more source

A Systematic Review of the Protective Actions of Cat’s Whiskers (Misai Kucing) on the Central Nervous System

Frontiers in Pharmacology, 2020
Orthosiphon stamineus (OS) or Orthosiphon aristatus var. aristatus (OAA) is commonly known as cat’s whiskers or “misai kucing”. It is an herbaceous shrub that is popular in many different traditional and complementary medicinal systems.
Yin-Sir Chung, Yin-Sir Chung, Brandon Kar Meng Choo, Pervaiz Khalid Ahmed, Pervaiz Khalid Ahmed, Iekhsan Othman, Iekhsan Othman, Mohd. Farooq Shaikh   +7 more
doaj   +1 more source

Compensate for or Minimize Matrix Effects? Strategies for Overcoming Matrix Effects in Liquid Chromatography-Mass Spectrometry Technique: A Tutorial Review

Molecules, 2020
In recent decades, mass spectrometry techniques, particularly when combined with separation methods such as high-performance liquid chromatography, have become increasingly important in pharmaceutical, bio-analytical, environmental, and food science ...
Manuela Cortese, M. R. Gigliobianco, Federico Magnoni, R. Censi, P. Di Martino   +4 more
semanticscholar   +1 more source

Clinical laboratory use of liquid chromatography mass spectrometry

Türk Biyokimya Dergisi, 2022
Mass spectrometric methods, which transition from chemistry laboratories to clinical laboratories in the basic field, are frequently used in areas such as metabolic analysis, endocrinology, drug research, protein studies and toxicology.
Unlu Ali, Abusoglu Sedat
doaj   +1 more source

Liquid Chromatography–Tandem Mass Spectrometry in Newborn Screening Laboratories

International Journal of Neonatal Screening, 2022
Tandem mass spectrometry (MS/MS) is the most universal platform currently available for the analysis of enzymatic activities and biomarkers in dried blood spots (DBS) for applications in newborn screening (NBS).
Michael H. Gelb, Khaja Basheeruddin, Alberto Burlina, Hsiao-Jan Chen, Yin-Hsiu Chien, George Dizikes, Christine Dorley, Roberto Giugliani, Amy Hietala, Xinying Hong, Shu-Min Kao, Hamid Khaledi, Tracy Klug, Francyne Kubaski, Hsuan-Chieh Liao, Monica Martin, Adrienne Manning, Joseph Orsini, Yin Peng, Enzo Ranieri, Andreas Rohrwasser, Nicolas Szabo-Fresnais, Coleman T. Turgeon, Frédérick M. Vaz, Li-yun Wang, Dietrich Matern   +25 more
doaj   +1 more source

Automated Coupling of Nanodroplet Sample Preparation with Liquid Chromatography-Mass Spectrometry for High-Throughput Single-Cell Proteomics.

Analytical Chemistry, 2020
Single-cell proteomics can provide critical biological insight into the cellular heterogeneity that is masked by bulk-scale analysis. We have developed a nanoPOTS (nanodroplet processing in one pot for trace samples) platform and demonstrated its broad ...
Sarah M. Williams, A. Liyu, Chia-Feng Tsai, Ronald J. Moore, D. Orton, W. Chrisler, Matthew J. Gaffrey, Tao Liu, Richard D. Smith, R. Kelly, L. Paša-Tolić, Ying Zhu   +11 more
semanticscholar   +1 more source

Malaysian Cobra Venom: A Potential Source of Anti-Cancer Therapeutic Agents

Toxins, 2019
Cancer is a deadly disease and there is an urgent need for the development of effective and safe therapeutic agents to treat it. Snake venom is a complex mixture of bioactive proteins that represents an attractive source of novel and naturally-derived ...
Syafiq Asnawi Zainal Abidin, Yee Qian Lee, Iekhsan Othman, Rakesh Naidu   +3 more
doaj   +1 more source