Results 41 to 50 of about 722,813 (296)

Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Simultaneous Determination of Antipsychotic Drugs in Human Plasma and Its Application in Therapeutic Drug Monitoring

Drug Design, Development and Therapy, 2021
Yingjie Qi, Guangxuan Liu Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, Liaoning Province, People’s Republic of ChinaCorrespondence: Yingjie QiDepartment of Pharmacy,
Qi Y, Liu G
doaj  

Liquid Chromatography Tandem Mass Spectrometry Quantification of ¹³C-Labeling in Sugars

Metabolites, 2020
Subcellular compartmentation has been challenging in plant 13C-metabolic flux analysis. Indeed, plant cells are highly compartmented: they contain vacuoles and plastids in addition to the regular organelles found in other eukaryotes.
Jean-Christophe Cocuron, Zacchary Ross, Ana P. Alonso   +2 more
doaj   +1 more source

Preventing false negatives with high-resolution mass spectrometry: the benzophenone case [PDF]

, 2016
Benzophenone (BP) is one of the many contaminants reported as present in foodstuff due to its migration from food packaging materials. Liquid chromatography tandem mass spectrometry (LC-MS/MS) is acknowledged in the literature as the method of choice for
Galcerán Huguet, M. Teresa, Gallart Ayala, Hèctor, Martins, Cláudia P. B., Moyano Morcillo, Encarnación, Núñez Burcio, Oscar   +4 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Liquid chromatography-tandem mass spectrometry - Application in the clinical laboratory [PDF]

, 2003
This review provides a concise survey of liquid chromatography tandem mass spectrometry (LCTMS) as an emerging technology in clinical chemistry. The combination of two mass spectrometers with an interposed collision cell characterizes LCTMS as an ...
Ford RE, Kushnir MM, Kushnir MM, Muck W, Murdter TE, Rashed MS, Streit F, Taylor RL   +7 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Workflow automation in liquid chromatography mass spectrometry [PDF]

, 2019
We describe the fully automated workflow path developed for the ingest and analysis of liquid chromatography mass spectrometry (LCMS) data. With the help of this computational workflow, we were able to replace two human work days to analyze data with two
Baidoo, E, Gentz, R, Martin, HG, Peisert, S   +3 more
core  

Carbon isotopic (C-13 and C-14) composition of synthetic estrogens and progestogens [PDF]

, 2012
RATIONALE: Steroids are potent hormones that are found in many environments. Yet, contributions from synthetic and endogenous sources are largely uncharacterized.
Aelion, Atkinson, Becchi, Beck, Boothby, Braga, Buisson, Caldwell, Chikaraishi, Coplen, Coppen, Cornet, Djerassi, Eglinton, Elsner, Flenker, Haubert, Ingalls, Isobe, Jasper, Johnson, Johnson, Kolpin, Krueger, Kumar, Levin, Liu, Morgan, Mortensen, Nakamura, O'Leary, Pataki, Philp, Piper, Piper, Reddy, Reddy, Reddy, Reddy, Robinson, Ruff, Schmidt, Sheesley, Smith, Sobolevskii, Strahm, Stuiver, Stuiver, Synal, Torre, Ueki, Wacker, Wacker, Whiticar, Wiechert, Yeh   +55 more
core   +2 more sources

Bayesian ABC-MCMC Classification of Liquid Chromatography–Mass Spectrometry Data

Cancer Informatics, 2015
Proteomics promises to revolutionize cancer treatment and prevention by facilitating the discovery of molecular biomarkers. Progress has been impeded, however, by the small-sample, high-dimensional nature of proteomic data.
Upamanyu Banerjee, Ulisses M. Braga-Neto
doaj   +1 more source

Bile acids: analysis in biological fluids and tissues

Journal of Lipid Research, 2010
The formation of bile acids/bile alcohols is of major importance for the maintenance of cholesterol homeostasis. Besides their functions in lipid absorption, bile acids/bile alcohols are regulatory molecules for a number of metabolic processes.
William J. Griffiths, Jan Sjövall
doaj   +1 more source