Results 61 to 70 of about 607,507 (319)

Optimization of a portable liquid scintillation counting device for determining 222Rn in water [PDF]

Radiation Measurements, 2018
The new EU Council Directive 2013/51/Euratom of 22 October 2013 introduced limits for the content of 222Rn in drinking water. Radon analysis in water requires a lengthy task of collection, storage, transport and subsequent measurement in a laboratory. A portable liquid scintillation counting device allows rapid sampling with significant savings of time,
arxiv   +1 more source

Synthesis of endohedral iron-fullerenes by ion implantation [PDF]

, 2015
In this paper, we discuss the results of our study of the synthesis of endohedral iron-fullerenes. A low energy Fe+ ion beam was irradiated to C60 thin film by using a deceleration system. Fe+-irradiated C60 thin film was analyzed by high performance liquid chromatography and laser desorption/ionization time-of-flight mass spectrometry. We investigated
arxiv   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Characterisation of Silicon Photomultipliers for Liquid Xenon Detectors [PDF]

, 2018
Silicon Photomultipliers (SiPMs) are considered as a solid-state sensor alternative to photomultiplier tubes in experiments using liquid xenon (LXe) as a radiation detection medium. The main requirements are single-photon detection of the vacuum ultraviolet scintillation light from LXe at 178$\,$nm with high resolution and detection efficiency and low ...
arxiv   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Galaxy-M: a Galaxy workflow for processing and analyzing direct infusion and liquid chromatography mass spectrometry-based metabolomics data

GigaScience, 2016
BackgroundMetabolomics is increasingly recognized as an invaluable tool in the biological, medical and environmental sciences yet lags behind the methodological maturity of other omics fields.
R. L. Davidson, Ralf J. M. Weber, Haoyu Liu, A. Sharma-Oates, M. Viant   +4 more
semanticscholar   +1 more source

Liquid chromatography mass spectrometry-based proteomics: Biological and technological aspects [PDF]

Annals of Applied Statistics 2010, Vol. 4, No. 4, 1797-1823, 2011
Mass spectrometry-based proteomics has become the tool of choice for identifying and quantifying the proteome of an organism. Though recent years have seen a tremendous improvement in instrument performance and the computational tools used, significant challenges remain, and there are many opportunities for statisticians to make important contributions.
arxiv   +1 more source

Workflow automation in liquid chromatography mass spectrometry [PDF]

, 2019
We describe the fully automated workflow path developed for the ingest and analysis of liquid chromatography mass spectrometry (LCMS) data. With the help of this computational workflow, we were able to replace two human work days to analyze data with two
Baidoo, E, Gentz, R, Martin, HG, Peisert, S   +3 more
core  

LC‐HRMS for the Identification of β‐Carboline and Canthinone Alkaloids Isolated from Natural Sources [PDF]

, 2017
β-carboline and canthinone alkaloids are widely distributed in the Angiosperms. Due to their diverse biological activities, the structures of these alkaloids have been used as important models for the synthesis of novel therapeutic drugs.
Amaral, Ana Claudia F., Chaves, Marcelo Henrique da C., da Cruz, Jefferson D., de Lima, Iasmim C., De Luna, Adélia Viviane M., dos Santos, Arith R., Ferreira, José Luiz P., Nery, Vinicius Vaz C., Ramos, Aline de S., Silva, Jefferson Rocha de A.   +9 more
core   +2 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source