Results 191 to 200 of about 177,363 (264)

Microenvironment‐Responsive Biomimetic Hydrogels Delivering Cistanche Deserticola‐Derived Nanovesicles for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
An injectable, microenvironment‐responsive hydrogel (HAPOCS@CDNVs) is developed for sustained delivery of Cistanche deserticola‐derived nanovesicles (CDNVs). By scavenging ROS, restoring mitochondrial function, and attenuating SASP, this platform effectively suppresses nucleus pulposus cell senescence and facilitates extracellular matrix reconstruction,
Ning Xu, Xiaoyu Cai, Xiaofu Tang, Weidong Liang, Linsong Teng, Yudong Jing, Haifeng Hu, Yuhao Duan, Mingjie Kuang, Lei Zhang, Shijie Han, Weibin Sheng   +11 more
wiley   +1 more source

Detection and quantification of ezetimibe and its major glucuronide in patients with hepatic impairment via liquid chromatography-tandem mass spectrometry. [PDF]

J Pharm Biomed Anal
Farrera DO, Maloney MM, LaMadrid CS, Lenzen-Hammerel P, Radtke LR, Cherrington NJ.   +5 more
europepmc   +1 more source

Self‐Included Fluorescent Probes via Azocalix[4]arene–Dye Conjugation for Activatable and Stable NIR Imaging

Advanced Science, EarlyView.
Self‐Included Fluorescent Probes (SIFPs), composed of self‐included macrocyclic carrier‐dye conjugates, encapsulate and protect covalently attached dyes, preventing leakage and enhancing stability. Azocalixarene‐based hypoxia activation enables precise tumor‐specific imaging.
Shun‐Yu Yao, Ze‐Han Wang, Chenyin He, Lidian Zheng, An‐Kang Ying, Kang Cai, Ai‐Feng Liu, Xiufeng Xiao, Dong‐Sheng Guo   +8 more
wiley   +1 more source

Improving the Detection of Analyte Degeneracies in Untargeted Liquid Chromatography-Tandem Mass Spectrometry Data. [PDF]

Anal Chem
Cain CN, Ma CH, Popov P, Kennedy RT.
europepmc   +1 more source

Matrix Stiffness Promotes Tumor Metastasis by Triggering Recycling Endosome‐Mediated YY1 Nuclear Translocation and Transcriptional Activity

Advanced Science, EarlyView.
In stiff extracellular matrix (ECM), integrin αVβ3 transduces mechanical cues of ECM stiffness to promote recycling endosome formation, creating a signaling platform for yin yang 1 (YY1)/p21‐activated kinase 4 (PAK4) binding, but not in soft ECM. Then, this triggers PAK4‐mediated YY1 phosphorylation at S118, subsequent YY1 nuclear translocation and ...
Fuqiang Zhao, Xinpeng Wen, Jingyi Liu, Hongqiang Yu, Tianzhu Cui, Makoto Miyagishi, Vivi Kasim, Shourong Wu   +7 more
wiley   +1 more source

Liquid chromatography-tandem mass spectrometry methods for clinical quantitation of antibiotics. [PDF]

Bioanalysis
He X, Zhang W, Xie F.
europepmc   +1 more source

Targeting Kynurenine Synthesis Attenuated Cigarette Smoke‐Induced COPD‐Like Lung Injury Driven by TALDO1‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Cigarette smoke induces airway epithelial TALDO1 upregulation and L‐kynurenine accumulation, driving mitochondrial injury with elevated mtROS, reduced Δψm, ATP, and OCR. This links to lung inflammation, alveolar destruction, and lung function damage, all attenuated by Epacadostat or Taldo1 reduction.
Wenjing Wang, Mindan Wu, Yuanlan Yang, Zemin Chen, Jiawei Yan, Xuan Jin, Yachao Cui, Feng Zhang, Haiqing Li, Wensheng Chen, Yumin Zhou, Leqing Zhu, Wei Tu, Pixin Ran   +13 more
wiley   +1 more source

Determination of 116 Pharmaceuticals and Personal Care Products in Water by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry. [PDF]

J Sep Sci
Xue M, Hong Y, Lu Y, Liu S, Wu H.
europepmc   +1 more source

Deciphering Intricacies in Directional CO2 Conversion From Electrolysis to CO2 Batteries

Advanced Energy Materials, EarlyView.
This review will delve into the inherent connections and distinctions of CO2‐directed conversion in ECO2RR and CO2 batteries, in terms of product types, catalyst selection, catalytic mechanisms, and electrochemical performances, while proposing a benchmarking framework for the evaluation of CO2 batteries and innovative CO2 battery configurations for ...
Changfan Xu, Huaping Zhao, Lizhuang Chen, Weidong Shi, Guosheng Shao, Yong Lei   +5 more
wiley   +1 more source

Serum Proteomic Analysis Using Gel-Based Liquid Chromatography Tandem Mass Spectrometry Reveals Differences Between Canine Oral Malignancies and Non-Malignant Conditions. [PDF]

Vet Med Sci
Ploypetch S, Roytrakul S, Jaresitthikunchai J, Phaonakrop N, Suriyaphol G.   +4 more
europepmc   +1 more source