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Liquid Chromatography–Tandem Mass Spectrometry for Clinical Diagnostics

open access: yesNature Reviews Methods Primers, 2022
Mass spectrometry is a powerful analytical tool used for the analysis of a wide range of substances and matrices; it is increasingly utilized for clinical applications in laboratory medicine. This Primer includes an overview of basic mass spectrometry concepts, focusing primarily on tandem mass spectrometry.
William Clarke   +2 more
exaly   +5 more sources
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Determination of dalcetrapib by liquid chromatography–tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis, 2012
The cholesteryl ester transfer protein modulator dalcetrapib is currently under development for the prevention of dyslipidemia and cardiovascular disease. Dalcetrapib, a thioester, is rapidly hydrolyzed in vivo to the corresponding thiophenol which in turn is further oxidized to the dimer and mixed disulfides (where the thiophenol binds to peptides ...
Katja, Heinig   +9 more
openaire   +2 more sources

A liquid chromatography tandem mass spectrometry method for plasma glucagon

Analytical Biochemistry, 2023
Glucagon is a peptide involved in controlling the body's blood glucose levels. The majority of analytical methods used for its quantitation are based on immunoassays that suffer from cross-reactivity with other peptides. For accurate routine analysis a liquid chromatography tandem mass spectrometry (LC-MSMS) was developed.
Van Long, Nguyen   +3 more
openaire   +2 more sources

Liquid chromatography tandem mass spectrometry in the clinical laboratory

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2014
Clinical laboratory medicine has seen the introduction and evolution of liquid chromatography tandem mass spectrometry in routine clinical laboratories over the last 10–15 years. There still exists a wide diversity of assays from very esoteric and highly specialist manual assays to more simplified kit-based assays.
Joanne E, Adaway   +2 more
openaire   +2 more sources

Mediator lipidomics by liquid chromatography-tandem mass spectrometry

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017
Comprehensive quantitative analysis of lipid mediators using liquid chromatography-tandem mass spectrometry is an effective strategy in the elucidation of disease mechanisms; but technically, it has been and is still a great challenge to achieve reliable datasets that cover variety of lipid metabolites contained at trace levels in complex biological ...
Yoshihiro, Kita   +2 more
openaire   +2 more sources

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