Results 231 to 240 of about 177,363 (264)
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Identification of gentamicin impurities by liquid chromatography tandem mass spectrometry
Journal of Pharmaceutical and Biomedical Analysis, 2009An HPLC/MS/MS method was developed for identification of impurities in gentamicin. The HPLC was performed on a Synergy Hydro-RP column using 50 mM trifluoroacetic acid (TFA), pH 2 adjusted with ammonium solution and methanol as mobile phase. All impurities in gentamicin were separated from main gentamicin components.
Rok, Grahek, Lucija, Zupancic-Kralj
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Quantitation of Bupropion in Urine by Liquid Chromatography-Tandem Mass Spectrometry
2023Bupropion is a medication commonly used to treat depression and help people quit smoking. However, it has the potential to be misused or diverted, so it is important to have accurate and sensitive methods to detect it in bodily fluids. We present a fast and dependable quantitative LC-MS/MS method for measuring bupropion levels in urine.
Xu, Li +2 more
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Determination of serum amantadine by liquid chromatography-tandem mass spectrometry
Clinica Chimica Acta, 2005Amantadine (1-adamantylamine) is used for treatment of influenza, hepatitis C, parkinsonism, and multiple sclerosis. Current amantadine analysis by HPLC or gas chromatography (GC) requires a laborious sample pretreatment with extraction and/or derivatization steps.
Torsten, Arndt +3 more
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Shotgun Protein Analysis by Liquid Chromatography-Tandem Mass Spectrometry
2009Two-dimensional electrophoresis (2DE) is an excellent technology for the analysis of complex protein mixtures, but it has drawbacks, such as hardly detecting very hydrophobic proteins. Shotgun protein analysis is one of the major technologies used to compensate for the weaknesses of 2DE.
Kazuishi, Kubota +2 more
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The role of liquid chromatography–tandem mass spectrometry in the clinical laboratory
Journal of Chromatography B, 2012Liquid chromatography coupled to mass spectrometry (LC-MS/MS) is increasingly used as a routine methodology in clinical laboratories for the analysis of low molecular weight molecules. The high specificity in combination with high sensitivity and multi-analyte potential makes it an attractive complementary method to traditional methodology used for ...
Johannes M W, van den Ouweland +1 more
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High-throughput chiral liquid chromatography/tandem mass spectrometry
Rapid Communications in Mass Spectrometry, 2000Chiral liquid chromatography is a well-established area of bioanalytical chemistry and is often used during the processes of drug discovery and development. The development and use of a chiral drug require the understanding of the pharmacokinetic characteristics of each of the enantiomers, including potential differences in their absorption ...
R, Bakhtiar, F L, Tse
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Quantitation of Albumin in Urine by Liquid Chromatography Tandem Mass Spectrometry
2016Urinary excretion of human serum albumin (HSA), a 6.65 kDa monomeric protein, is a sensitive marker of renal damage associated with many diseases including diabetes mellitus. Albumin is synthesized by the liver and functions as a transport protein for fat-soluble hormones and drugs and for maintaining plasma colloid osmotic pressure and pH.
Hemamalini, Ketha, Ravinder J, Singh
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Determination of aldosterone in serum by liquid chromatography–tandem mass spectrometry
Journal of Chromatography B, 2008Measurement of serum aldosterone is clinically important in the diagnosis of hypertension. While isotope dilution gas chromatography-mass spectrometry (ID-GC-MS) provides reliable results, it requires derivatization and is lengthy and time-consuming. Detection by liquid chromatography-mass spectrometry (LC-MS) is a potentially superior method.
Ursula, Turpeinen +2 more
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Liquid Chromatography−Tandem Mass Spectrometry of Some Anabolic Steroids
Analytical Chemistry, 1999In this paper a procedure is described for the analysis of 36 anabolic steroids, regularly found in kidney fat matrixes. After preparative HPLC is carried out, six fractions, containing the different steroids, were obtained. These fractions were then separated and on-line mass-analyzed, using APcI LC/MS. When used in tandem mass spectrometry (MRM) mode,
P E, Joos, M, Van Ryckeghem
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Determination of testosterone in serum by liquid chromatography-tandem mass spectrometry
Scandinavian Journal of Clinical and Laboratory Investigation, 2008Commercial direct immunoassays for serum testosterone sometimes result in inaccuracies in samples from women and children, leading to misdiagnosis and inappropriate treatment. The diagnosis of male hypogonadism also requires an accurate testosterone assay method.
U, Turpeinen +3 more
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