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Pharmacokinetics of HZ08 in rats by liquid chromatography–tandem mass spectrometry
Journal of Chromatography B, 2007A selective and sensitive liquid chromatographic method coupled with ion spray tandem mass spectrometry detection (LC-MS/MS) was developed for the determination and pharmacokinetic study of N-cyano-1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide (HZ08, a candidate reversing agent for multidrug ...
Jing-yan, Weng +4 more
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Pain Management Testing by Liquid Chromatography Tandem Mass Spectrometry
Clinics in Laboratory Medicine, 2018For appropriate pain medication monitoring, the analytical method must be sensitive enough to detect the prescribed medication and metabolites at a sufficiently low concentration to recognize compliance, even with a low-dose prescription. The method must also provide excellent selectivity to identify simultaneously present drugs even with similar ...
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Quantification of Designer Opioids by Liquid Chromatography–Tandem Mass Spectrometry
2018Opioids including heroin and commonly prescribed drugs such as oxycodone and fentanyl are among the most commonly abused drugs. In recent years, the abuse of opioids has spread beyond these commonly encountered analytes and now includes novel psychoactive drugs such as AH-7921 and U47700 and a variety of fentanyl-related compounds such as acetyl ...
Sherri L, Kacinko, Joseph W, Homan
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Quantification of Melatonin with Immunoassay and Liquid Chromatography-Tandem Mass Spectrometry
Melatonin, a key hormone in regulating circadian rhythms and sleep-wake cycles, presents challenges for quantification in C57BL/6 mice. C57BL/6 mice are the most used mouse strain for laboratory studies due to their inherent melatonin deficiency. This strain exhibits very low or undetectable melatonin levels in the pineal gland and blood, complicating ...Jonah, Kutell +3 more
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Liquid Chromatography Tandem Mass Spectrometry in the Clinical Laboratory
Annals of Clinical Biochemistry, 2015Brian Keevil, Joanne Adaway
exaly