Results 31 to 40 of about 177,363 (264)

Harmonization of Liquid Chromatography–Tandem Mass Spectrometry Protein Assays [PDF]

Clinics in Laboratory Medicine, 2018
Harmonization of diagnostic test results is fundamental to the effective use of laboratory testing in the diagnosis, treatment, and monitoring of disease. Formal approaches to harmonization and standardization provide a rigorous and high-quality roadmap to this end, although the formal harmonization process can be long and complex.
Alan L, Rockwood, Mark S, Lowenthal, Cory, Bystrom   +2 more
openaire   +2 more sources

Evaluation of uncertainty in determination of methamidophos residue in vegetable oil by ultra- performance liquid chromatography-tandem mass spectrometry

Shipin yu jixie
ObjectiveTo evaluation the uncertainty of determination of methamidophos residues in vegetable oil by ultra-performance liquid chromatography-tandem mass spectrometry.MethodsA vegetable oil sample was detected by ultra-high performance liquid ...
GAO Han, LIU Rui, JIANG Cheng, WANG Feifei   +3 more
doaj   +1 more source

Determination of glyphosate and AMPA in freshwater and soil from agroecosystems by 9-fluorenylmethoxycarbonyl chloride derivatization and liquid chromatography - fluorescence detection and tandem mass spectrometry

MethodsX, 2022
The herbicide glyphosate (GLY) and its metabolite aminophosphonic acid (AMPA) are troublesome compounds for analysis in the environment. Here we report a reliable technique for GLY and AMPA determination in freshwater and soils by means of derivatization
Beatriz Alonso, Luciana Griffero, Heinkel Bentos Pereira, Lucía Pareja, Andrés Pérez Parada   +4 more
doaj   +1 more source

Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry [PDF]

Clinical Chemistry and Laboratory Medicine (CCLM), 2005
AbstractA convenient liquid chromatography-tandem mass spectrometry method for the quantification of the triazole antifungal agent voriconazole in plasma samples is described. Fenbuconazole is used as an internal standard. After protein precipitation, automated solid-phase extraction is applied.
Vogeser, Michael, Schiel, Xaver, Spöhrer, Ute   +2 more
openaire   +3 more sources

Recent applications of liquid chromatography tandem mass spectrometry at various stages of drug development

Future Journal of Pharmaceutical Sciences
Background Liquid chromatography–tandem mass spectrometry is a combination of liquid chromatography and mass spectrometry. In this process, high-performance liquid chromatography separates analytes, ionizes them, and then analyzes them using mass filters
Sunita Sunil Gagare, Vaishnavi Bhau Thorat, Ashish Suresh Jain   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Data supporting the rat brain sample preparation and validation assays for simultaneous determination of 8 neurotransmitters and their metabolites using liquid chromatography–tandem mass spectrometry

Data in Brief, 2016
The data presented in this article supports the rat brain sample preparation procedure previous to its injection into the liquid chromatography–tandem mass spectrometry (LC–MS/MS) system to monitor levels of adrenaline, noradrenaline, glutamic acid, γ ...
Aneta Wojnicz, José Avendaño Ortiz, Ana I. Casas, Andiara E. Freitas, Manuela G. López, Ana Ruiz-Nuño   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

ANALYTICAL FEATURES OF SYNTHETIC MDMB(N)-073F CANNABIMIMETICS AND ITS MARKERS IN BIOLOGICAL MATERIAL

Фармация и фармакология (Пятигорск), 2019
The aim of the research is to study both analytical features of synthetic MDMB(N)-073F cannabimimetics of indazole carboxamides group by gas chromatography methods combined with tandem mass spectrometry (GC-MS) and high performance liquid chromatography ...
S. S. Kataev, O. N. Dvorskaya, M. A. Gofenberg, A. V. Labutin, A. B. Melentyev   +4 more
doaj   +1 more source