Results 141 to 150 of about 2,711,229 (306)

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Liquid chromatography-mass spectrometry approaches for analysis of polychlorinated alkanes: a review. [PDF]

Environ Sci Pollut Res Int
Lazdiņa L, Pērkons I.
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Evaluating the Effect of Chromatographic Chelator Modifiers on Metabolite Levels in Untargeted Liquid Chromatography-Mass Spectrometry. [PDF]

J Am Soc Mass Spectrom
Breiner DJ, Phelan VV.
europepmc   +1 more source

Natural Variation in ZmASB1 Links Tryptophan Metabolism to Root Growth and Drought Tolerance in Maize

Advanced Science, EarlyView.
Natural variation in the maize ZmASB1 promoter regulates tryptophan accumulation, root development, and drought tolerance through a tryptophan–auxin pathway. A 5‐bp InDel alters ZmDOF17 binding and promoter activity, and the favorable allele is enriched during breeding. These findings reveal a cis‐regulatory mechanism linking amino acid metabolism with
Xiaoyi Yang, Houmiao Wang, Xiaomin Zhang, Yunyun Wang, Yimei Tian, Baoqing Wang, Tianze Zhu, Shuai Fang, Wei Li, Wenye Rui, Yining Zhang, Dan Sun, Haoxin Gao, Yuxuan Li, Zhongtao Jia, Zefeng Yang, Chenwu Xu, Pengcheng Li   +17 more
wiley   +1 more source

Modern Optimization Strategies in High-Performance Liquid Chromatography Analysis. [PDF]

J Sep Sci
Elagamy SH, Elattar RH.
europepmc   +1 more source

Insights Into CO2 Loss, pH Effects, and Tafel Kinetics in Ni Single Atom‐Driven Bicarbonate Electroreduction

Advanced Science, EarlyView.
Selective CO formation in bicarbonate electrolysis is achieved by retaining reactive CO2 and tuning pH, while the competing hydrogen evolution reaction occurs at the interface. The rate‐determining step couples the chemical equilibrium of bicarbonate/CO2 with electrochemical charge transfer, offering insight into optimizing reaction conditions for ...
Lin Li, Yi‐Jie Kong, Ting Zhang, Xu Han, Kristine Aalestrup, Steen Uttrup Pedersen, Xin‐Ming Hu, Kim Daasbjerg   +7 more
wiley   +1 more source

Ultra-high capacity liquid chromatography chip quadrupole time-of-flight mass spectrometry for pharmaceutical analysis

, 2011
Ultra-high capacity liquid chromatography chip/quadrupole time-of-flight mass spectrometry for pharmaceutical ...
赵春霞, 许国旺, XueGang, LinDayin, WangJian, XuZhixiu, HerbertGodel, 蔡恺阳, 吴泽明, 常玉玮, ZhaoYining   +10 more
core  

Predicting the Aqueous Solubility of Neutral Organic Compounds by Reversed-Phase Liquid Chromatography. [PDF]

J Sep Sci
Atapattu SN, Li J.
europepmc   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source