Results 51 to 60 of about 2,144,960 (237)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Thin aligned organic polymer films for liquid crystal devices [PDF]

open access: yes, 1997
This project was designed to investigate the possibility of producing alignment layers for liquid crystal devices by cross-linking thin films containing anisotropic polymer bound chromophores via irradiation with polarised ultra violet light.
Foster, Kathryn Ellen
core  

Characterization and Biocompatibility Study of Nematic and Cholesteryl Liquid Crystals. [PDF]

open access: yes, 2009
NoIntensive research in bio-engineering has been conducted in the search for flexible biomaterials that could support cell growth and cells attachment.
Denyer, Morgan C.T.   +6 more
core   +4 more sources

The Effects of Network Architecture on the Photomechanical Performance of Azo-Acrylate Liquid Crystal Elastomers

open access: yesCrystals
Azo-containing liquid crystal elastomers are photomechanical materials that can be actuated via illumination. The photomechanical response is a result of the photoisomerization of the azo moiety, which produces bulk stresses in the material.
Anastasiia Svanidze   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Effects of Photopatterning Conditions on Azimuthal Surface Anchoring Strength

open access: yesCrystals
Spatially varying alignment of liquid crystals is essential for research and applications. One widely used method is based on the photopatterning of thin layers of azo-dye molecules, such as Brilliant Yellow (BY), that serve as an aligning substrate for ...
Nilanthi P. Haputhanthrige   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Anchoring energy enhancement and pretilt angle control of liquid crystal alignment on polymerized surfaces

open access: yesAIP Advances, 2015
We demonstrate enhanced surface anchoring energy and control of pretilt angle in a nematic liquid crystal cell with vertical alignment and polymerized surfaces (PS-VA).
Libo Weng   +6 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

Bistable nematic liquid crystal device with flexoelectric switching

open access: yes, 2006
Motivated generally by potential applications in the liquid crystal display industry [8,35], and specifically by recent experimental, theoretical and numerical work [6,7,13,14,21,25,30,31], we consider a thin film of nematic liquid crystal (NLC ...
RICHARDSON, Giles, CUMMINGS, L.J.
core   +1 more source

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