Results 91 to 100 of about 5,187,739 (314)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Photothermal Transport for Guiding Nanoparticles Through the Vitreous Humor

Advanced Science
Visual impairments affect over 2.2 billion people worldwide, yet delivering drugs to the posterior segment of the eye, including the retina, remains a major challenge. Intravitreal injection, the standard administration route, often results in suboptimal
Léa Guerassimoff, Yera Ussembayev, Louise De Clerck, Deep Punj, Martijn van den Broek, Filip Beunis, Katrien Remaut, Kevin Braeckmans, Stefaan C. De Smedt, Félix Sauvage   +9 more
doaj   +1 more source

Design and verification of an umbrella shaped narrow band - UWB antenna pair for MIMO applications using characteristic mode analysis

e-Prime: Advances in Electrical Engineering, Electronics and Energy
Using characteristic mode analysis (CMA), a pair of ultra-wideband (UWB) and narrow band antennas is made. The Multiple Input Multiple Output (MIMO) configuration incorporates a circular monopole to attain UWB functionality, while an umbrella-shaped ...
Chandra Suresh Ankireddy, T. Sreenivasulu Reddy, B T P Madhav   +2 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Ferroelectric Liquid Crystals: Physics and Applications

Crystals, 2016
Electrooptic modes with fast response and high contrast ratio are highly desirable in modern photonics and displays. Ferroelectric liquid crystals (FLCs) are especially promising for fulfilling these demands by employing photoalignment technology in FLC ...
Q. Guo, Kexin Yan, V. Chigrinov, Huijie Zhao, M. Tribelsky   +4 more
semanticscholar   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Composition Dependence of the Structure and Electronic Properties of Liquid Ga-Se Alloys Studied by Ab Initio Molecular Dynamics Simulation

, 1995
Ab initio molecular dynamics simulation is used to study the structure and electronic properties of the liquid Ga-Se system at the three compositions Ga$_2$Se, GaSe and Ga$_2$Se$_3$, and of the GaSe and Ga$_2$Se$_3$ crystals.
A. Kuhn, D. J. Chadi, D. M. Ceperley, G. A. de Wijs, G. Galli, G. I. Abutalybov, G. Kresse, G. Kresse, G. Lehmann, G. P. Kerker, I. Stich, J. C. Mikkelsen, J. C. Valiant, J. E. Enderby, J. E. Enderby, J. M. Holender, J. M. Holender, J. Perdew, J. V. McCanny, K. Popp, L. Kleinman, M. C. Bellissent-Funel, M. C. Payne, M. Inui, M. J. Gillan, M. J. Gillan, M. P. Grumbach, M. Schlüter, M. Schöne, N. F. Mott, O. Jepsen, P. Gomes da Costa, P. S. Benazeth, Q. M. Zhang, R. Car, R. D. King-Smith, R. W. Schmutzler, S. Takeda, T. Okada, W. Hoyer, W. Hoyer, X. G. Gong   +41 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Tuning the Electrical Resistivity of Molecular Liquid Crystals for Electro-Optical Devices

Engineering Proceedings
Modern applications of molecular liquid crystals span from high-resolution displays for augmented and virtual reality to miniature tunable lasers, reconfigurable microwave devices for space exploration and communication, and tunable electro-optical ...
Michael Gammon, Iyanna Trevino, Michael Burnes, Noah Lee, Abdul Saeed, Yuriy Garbovskiy   +5 more
doaj   +1 more source

Swollen liquid crystals (SLCs): a versatile template for the synthesis of nano structured materials

, 2017
Liquid crystal (LCs) is the state of matter that exhibits properties between a conventional liquid and solid crystals. Liquid crystals mainly can be classified into two types: thermotropic and lyotropic liquid crystals.
S. Dutt, P. Siril, S. Remita
semanticscholar   +1 more source