Results 31 to 40 of about 933 (258)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Gas-holdup in a 16.6 cm I.D. reciprocating plate column [PDF]

Hemijska Industrija, 2005
The effects of operation conditions (the vibration intensity and gas flow rate) on the gas holdup in a 16.6 cm i.d. two-phase reciprocating plate column (RPC) were studied.
Vasić Ljubiša S., Banković-Ilić Ivana B., Lazić Miodrag L., Veljković Vlada B., Skala Dejan U.   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

CFD study and experimental validation of low liquid-loading flow assurance in oil and gas transport: studying the effect of fluid properties and operating conditions on flow variables

Heliyon, 2020
Low liquid-loading flow frequently occurs during the transport of gas products in various industries, such as in the Oil & Gas, the Food, and the Pharmaceutical Industries.
Miguel Ballesteros Martínez, Eduardo Pereyra, Nicolás Ratkovich   +2 more
doaj   +1 more source

Improved Two-Fluid Model for Segregated Flow and Integrated Multiphase Flow Modeling for Downhole Pressure Predictions

Energies, 2023
This work presents an integrated multiphase flow model for downhole pressure predictions with the purpose of producing relatively more accurate predictions under wide-flowing conditions while maintaining a simple form.
Abdullah Alkhezzi, Yilin Fan
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Numerical Simulation of Gas-Liquid Flow in a Bubble Column by Intermittent Aeration in Newtonian Liquid/Non-Newtonian Liquid

International Journal of Chemical Engineering, 2018
The dynamic behaviors of gas-liquid two-phase flow were simulated in a lab-scale intermittent bubble column by Euler-Euler two-fluid model coupled with the PBM (population balance model) using two different liquid phases, i.e., Newtonian fluid (water ...
Zheng Xipeng, Wang Le, Jia Xiaoxuan, Xiang Wenchuan, Yang Shunsheng   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Modeling gas holdup in a multiphase oxygen slurry bubble column reactor for Cu-Cl hydrogen production using CFD

Results in Engineering
The hydrodynamics of the oxygen bubble column reactor is investigated numerically using CFD analyses to predict the values of the gas holdup using Eulerian model and k−ε turbulence method.
M.W. Abdulrahman
doaj   +1 more source