Results 81 to 90 of about 3,984,547 (275)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Efficiency of semi-automated culture systems on microtubers formation of yam (Dioscorea alata L.) [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2012
Yam clone 'Belep' in temporary immersion system showed favorable results on microtubers formation. Plants cultivated in this type of culture system were the first ones to initiate microtubers formation and produced the highest microtubers number per ...
Jova, MC., Kosky, RG., Cuellar, EE., Cuellar, AE.   +3 more
doaj  

Undang-Undang Republik Indonesia Nomor 11 Tahun 2012 Tentang Sistem Peradilan Anak

, 2015
Dalam buku ini terdapat beberapa hal yang dapat kita ketahui bersama meliputi, Acara Peradilan Anak, Petugas Kemasyarakatan, Pidana dan Tindakan, Pelayanan, Perawatan Pendidikan, serta Pembinaan dan Pembinaan Klien ...
Medium
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Growth and Protein Content Establishment of Pleurotus ostreatus on Liquid and Solid Medium

Biosaintifika: Journal of Biology & Biology Education, 2017
Pleurotus ostreatus cultivation is performed using solid medium to harvest fruit body and using liquid medium to harvest mycelia in submerged culture. Modifying nutrients in the medium to increase protein content of the fruitbody and mycelia can be done ...
Aris Mumpuni, Nuraeni Ekowati, Purnomowati Purnomowati, Endang Sri Purwati   +3 more
doaj   +1 more source

Liquid membrane extraction of bio-active amphiphilic substances: Recovery of surfactin [PDF]

, 2008
The interest of application of liquid membrane (pertraction) processes for recovery of biosurfactants from aqueous media was demonstrated. Transport of pure surfactin in three-liquid-phase system was studied.
Nikov, Iordan, Gancel, Frédérique, Montastruc, Ludovic, Dimitrov, Krasimir   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Special Commemorative Issue

, 1975
Newspaper publication from Liquid Paper Corporation on Letter Perfect, November 1975, with updates to staff and patrons about the on-goings and news updates regarding the ...
Liquid Paper Corporation
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Optimizing Micropropagation of Tanacetum balsamita L.: A Machine Learning Approach to Compare Semisolid Media and Temporary Immersion System

Horticulturae
Tanacetum balsamita L. is a medicinal and aromatic plant of high economic value, yet its tissue culture and micropropagation protocols remain poorly developed.
Carla Benelli, Cecilia Faraloni, Tolga İzgü, Özhan Şimşek, Waed Tarraf   +4 more
doaj   +1 more source