Results 41 to 50 of about 847,808 (255)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Пищевые системы, 2019 The formation of food liquid medium structures containing at least 70 % of disperse particles with high dispersiveness has been considered. The possible formation mechanisms of food liquid medium structure when slow (hydrodynamic) and quick (acoustic ...
T. V. Savenkova +4 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Numerical study of the process of unsteady flow in a three-layer porous medium
Magazine of Civil Engineering, 2023 The unsteady fluid flow in a three-layer porous medium is numerically investigated and is an important and topical problem. An analytical solution of the equation for the pressure fluid layer is obtained on the basis of the theory of elastic regime ...
Ravshanov Normahmad +3 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
CONCENTRATION OF LIQUID PES MEDIA ON THE GROWTH AND PHOTOSYNTHETIC PIGMENTS OF SEAWEEDS COTONII PROPAGULE (KAPPAPHYCUS ALVAREZII DOTY) THROUGH TISSUE CULTURE [PDF]
Russian Journal of Agricultural and Socio-Economic Sciences, 2018 In vitro tissue culture of Kappaphycus alvarezii, the required nutrients are derived from the culture medium. The use of liquid PES medium as a culture medium has been widely applied to increase the growth rate of seaweeds.
Lumbessy S.Y. +3 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
CHANGE OF MECHANICAL PROPERTIES OF THIN-LAYER MEMBRANES UNDER THE INFLUENCE OF LIQUID MEDIUM
Structural Mechanics of Engineering Constructions and Buildings, 2017 Thin-layer membranes and membrane compositions find application in different indus- tries as independent design elements and as coatings. With the development of new technolo- gies, functional coatings are become increasingly widespread.
SAMAT NUKHOVICH YAKUPOV +2 more
doaj +1 more source