Results 61 to 70 of about 83,550 (282)

A Streamlined High Performance Liquid Chromatography with Tandem Mass Spectrometry Based Workflow for Rapid Screening of Cellular Accumulation of Small Molecules

ChemMedChem, EarlyView.
This study uses six small‐molecule inhibitors to evaluate optimal cellular accumulation assay conditions in a 96‐well format with high performance liquid chromatography with tandem mass spectrometry detection. The obtained medium to high‐throughput workflow is suitable for reliably identifying cellular accumulation, valuable for preclinical selection ...
Alina Metzen, Katharina Rox
wiley   +1 more source

Guided Sample Pooling in Human Mass Balance Studies: A Recommended Strategic Decision Framework

Clinical Pharmacology &Therapeutics, EarlyView.
Radiolabeled human mass balance studies are crucial for identifying circulating metabolites and understanding drug absorption, excretion, and clearance pathways. Metabolite profiling involves quantifying all drug‐related entities, including parent drug and metabolites in plasma and excreta, using extended liquid chromatography methods coupled with ...
Filip Cuyckens, Wenying Li, Adam M. Auclair, Kenneth C. Cassidy, Cathy Cantalloube, Gary Collins, Alexander D. James, Chris Gibson, Ulrike Glaenzel, Felix Huth, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Pietro Brunetti, Hanno Schieferstein, David Wagner, Gregory S. Walker, Shuai Wang, Qin Yue, Jason Boer, Cyrus Khojasteh   +21 more
wiley   +1 more source

Combustion method for assay of biological materials labeled with carbon-14 or tritium, or double-labeled [PDF]

, 1969
Dry catalytic combustion at high temperatures is used for assaying biological materials labeled carbon-14 and tritium, or double-labeled. A modified oxygen-flask technique is combined with standard vacuum-line techniques and includes convenience of ...
Huebner, L. G., Kisieleski, W. E.
core   +1 more source

Application of a liquid scintillation counter to the measurement of tracing radioactivity in experiments on suspended matter uptake in aquatic environments [PDF]

, 2002
The experiments on the study of the kinetic transfer coefficients of conservative and non-conservative radionuclides, in aquatic environments, need to determine radionuclide activity in large number of samples.
Abril Hernández, José María, El Mrabet, Rachid, García-Tenorio García-Balmaseda, Rafael, Manjón Collado, Guillermo   +3 more
core   +1 more source

Fabrication of amorphous lamellar freestanding poly(N‐dodecyl acrylamide) films and their mechanical properties

Polymer International, EarlyView.
A freestanding film of completely uniaxially oriented amorphous lamellae was produced. The film exhibited enhanced tensile strength with increasing orientation of the lamella. Abstract An amorphous lamellar freestanding film composed of poly(N‐dodecyl acrylamide) (pDDA) was prepared by annealing a micrometer‐thick film under humid conditions (humid ...
Yuki Koizumi, Yoshimasa Matsuo, Akito Masuhara, Hinako Ebe, Yuya Ishizaki‐Betchaku, Shusaku Nagano, Jun Matsui   +6 more
wiley   +1 more source

High Efficiency Detection of Argon Scintillation Light of 128nm Using LAAPDs

, 2005
The possibility of efficient collection and detection of vacuum ultraviolet light as emitted by argon, krypton, and xenon gas is studied. Absolute quantum efficiencies of large area avalanche photodiodes (LAAPDs) are derived at these wavelengths.
Chandrasekharan, R., Knecht, A., Messina, M., Regenfus, C., Rubbia, A.   +4 more
core   +2 more sources

Azole antifungal contaminants disrupt mycorrhizal function and risk agricultural sustainability

PLANTS, PEOPLE, PLANET, EarlyView.
Global food production is increasingly threatened by soil degradation, climate change and the rising costs of synthetic fertilisers. Circular agriculture, which promotes resource reuse, is a promising solution, but using treated wastewater and biosolids in farming introduces risks from emerging contaminants like pharmaceutical residues.
Emily K. Durant, Katie J. Field, J. Brett Sallach, Sara Moeskjær, Alex Williams, Laura J. Carter   +5 more
wiley   +1 more source

Enrichment of Low-Level Tritium in Groundwater via an Electrolysis Process for Liquid Scintillation Counting Applications

Geosciences, 2023
Tritium levels in the groundwater of arid regions are very low; in most cases, these low tritium levels cannot be detected using a conventional liquid scintillation counter (LSC).
Al Mamun
doaj   +1 more source

A Current Mode Detector Array for Gamma-Ray Asymmetry Measurements

, 2004
We have built a CsI(Tl) gamma-ray detector array for the NPDGamma experiment to search for a small parity-violating directional asymmetry in the angular distribution of 2.2 MeV gamma-rays from the capture of polarized cold neutrons by protons with a ...
Achasov, Bakken, Blinchikoff, Bowman, C. Blessinger, Chowdhury, Csoto, Davenport, Desplanques, G.S. Mitchell, Gericke, Grassman, H. Nann, Horowitz, J. Hartfield, J. Tasson, J.D. Bowman, Knoll, Kobayashi, Komives, M. Leuschner, M.T. Gericke, Mitchell, Nelson, P.-N. Seo, Page, R.C. Gillis, Renker, S. Muto, S.A. Page, S.I. Penttilä, Schotanus, Seo, Snow, Snow, Snow, T. Ino, W.D. Ramsay, W.M. Snow, W.S. Wilburn, Wei, Winder, Y. Masuda, Zhu   +43 more
core   +1 more source

Design of Experiments (DoE)‐Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose‐to‐Brain Delivery

Small, EarlyView.
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad, Shunping Han, Rifka Utami, Rafal Baker, Dina Helal, Zhuoni Li, Mark Tricklebank, Yannis Paloyelis, Julie Wang, Marija M. Petrinovic, Sukhi Bansal, Khuloud T. Al‐Jamal   +11 more
wiley   +1 more source