Results 101 to 110 of about 1,266,256 (315)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Computational exploration of water structure and dynamics at heterogeneous interfaces [PDF]

, 2014
The goal of this thesis is to completely understand the dynamical behavior of water at different heterogeneous interfaces through statistical mechanics and computational methods.
Gupta, Prashant Kumar
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Speciation analysis of mercury in water samples by dispersive liquid-liquid microextraction coupled to capillary electrophoresis [PDF]

, 2014
In this study, a method of pretreatment and speciation analysis of mercury by dispersive liquid-liquid microextraction along with CE was developed. The method was based on the fact that mercury species including methylmercury (MeHg), ethylmercury (EtHg),
Yingying Wen, You, Jinmao, Ding, Yangjun, Jiping Ma, Chen, Lingxin, Li, Jinhua, Xiaoqiang Cai, Jinmao You, Fangfang Yang, Lingxin Chen, Wenhui Lu, Yangjun Ding, Yang, Fangfang, Cai, Xiaoqiang, Wen, Yingying, Ma, Jiping, Lu, Wenhui, Jinhua Li   +17 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Excess Electron Relaxation Dynamics at Water/Air Interfaces [PDF]

, 2007
We have performed mixed quantum-classical molecular dynamics simulations of the relaxation of a ground state excess electron at interfaces of different phases of water with air.
László Turi, Ádám Madarász, Peter J. Rossky, Turi, László, Madarász, Ádám, Rossky, Peter   +5 more
core   +1 more source

Development of a Liquid Scintillator Using Water for a Next Generation Neutrino Experiment

Advances in High Energy Physics, 2014
A feasibility study on a new type of liquid scintillator based on water has been performed. Mainly due to the differences in polarities between water and oil, organic solvents are not mixed in water. In order to make a liquid scintillator based on water,
Sun Heang So, Kyung Kwang Joo, Ba Ro Kim, Bong Keon Kim, Seung Chan Kim, Chang Dong Shin, In Sung Yeo   +6 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Implications of ideas on super-hydrophobicity for water repellent soil [PDF]

, 2007
Water repellence is an important factor in soil erosion due to its role in inhibiting the re-establishinent of vegetation after fire and due to its enhancement of run-off.
Pyatt, F. Brian, Newton, Michael, Newton, MI, Shirtcliffe, Neil, McHale, G, Shirtcliffe, NJ, McHale, Glen, Pyatt, FB   +7 more
core   +1 more source