Results 81 to 90 of about 1,266,256 (315)

Remarks on Life Feasibility on the Red Planet

Microorganisms
The current strong interest in the exploration of Mars leads to the question of the actual possibility of the presence or possible past or future development of life on the planet. Several clues suggest that liquid water could be stably present under the
Fiorella Mancini, Giuseppe Graziano
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Liquid water simulation using hydrogen bond corrected SCAN and neural network potentials.

, 2021
Accurately reproducing the structure of liquid water with ab initio molecular dynamics (AIMD) simulation is a crucial first step on the path towards accurately predicting the properties of liquid solutions without relying on experiment.
Timothy, Duignan
core   +1 more source

Translational-Rotational Decoupling Dynamics of High-Pressure Liquid Water under Quasi-Isentropic Compression

Gaoya wuli xuebao
The ubiquitous presence of water, from Earth and planetary bodies to interstellar space, renders its phase behavior across an extensive thermodynamic range fundamental to understanding key scientific phenomena such as biochemical reactions, climate ...
Changhao DENG, Bo CHEN, Jiayu DAI
doaj   +1 more source

Liquid water contains the building blocks of diverse ice phases

Nature Communications, 2020
Molecular understanding of water is challenging due to the structural complexity of liquid water and the large number of ice phases. Here the authors use a machine-learning potential trained on liquid water to demonstrate the structural similarity of ...
Bartomeu Monserrat, Jan Gerit Brandenburg, Edgar A. Engel, Bingqing Cheng   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Gas-Liquid Two-Phase Flow in Up and Down Vertical Pipes [PDF]

, 2013
Multiphase flows occurring in pipelines with a serpentine configuration is an important phenomenon, which can be encountered in heat exchangers used in a variety of industrial processes.
Almabrok, Almabrok Abushanaf
core  

Residence time distribution measurements in an external-loop airlift reactor: Study of the hydrodynamics of the liquid circulation induced by the hydrogen bubbles [PDF]

, 2011
A detailed study of the residence time distribution (RTD) analysis of liquid phase has been performed in an external-loop airlift reactor of 20 L nominal volume, regarded as a global unit and discriminating its different sections (riser, gas–liquid ...
A.H. Essadki, Vial, Christophe, Gourich, Bouchaib, Ch. Vial, H. Delmas, Essadki, Abdel Hafid, Delmas, Henri, B. Gourich   +7 more
core   +1 more source

Entropy-driven liquid–liquid separation in supercooled water [PDF]

Scientific Reports, 2012
Twenty years ago Poole et al. (Nature 360, 324, 1992) suggested that the anomalous properties of supercooled water may be caused by a critical point that terminates a line of liquid-liquid separation of lower-density and higher-density water. Here we present an explicit thermodynamic model based on this hypothesis, which describes all available ...
Holten, V., Anisimov, M. A.
openaire   +3 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source