Results 11 to 20 of about 9,532 (213)

FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence‐Associated Factor pMGF300‐2R [PDF]

Advanced Science, EarlyView.
ABSTRACT African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA ...
Rui Luo, Jing Zhang, Ruojia Huang, Xianfeng Zhang, Lian‐Feng Li, Jing Lan, Zhanhao Lu, Yuan Sun, Tao Wang, Hua‐Ji Qiu   +9 more
wiley   +2 more sources

Discovering host-viral protein interactions in autophagy: A LIR discovery pipeline for identifying LC3-interacting region motifs in highly virulent viruses. [PDF]

PLoS Pathogens
Hemorrhagic fever virus (HFV) infections are highly fatal, posing a significant global pandemic threat as they continue to emerge in new locations. HFVs and other highly virulent viruses (HVVs), such as Nipah virus, exploit host cell pathways, including ...
Kaylee D Petraccione, Haytham M Wahba, Mohamed G H Ali, Timothy Stocker, Ivan Akhrymuk, Yossira Swese, Danuta Sastre, Andrew Silberfarb, Paul E O'Maille, James G Omichinski, Kylene Kehn-Hall   +10 more
doaj   +2 more sources

The TaCOMT1A‐Synthesised Sakuranetin Is a Novel Biostimulant Enhancing Drought Tolerance and Yield in Wheat [PDF]

Plant Biotechnology Journal, EarlyView.
ABSTRACT Drought stress is a major limitation to global wheat production. Here, we demonstrate that the wheat gene TaCOMT1A, encoding a caffeic acid O‐methyltransferase, plays a crucial role in enhancing drought tolerance in wheat. Overexpression of TaCOMT1A significantly improved drought tolerance at the seedling stage, as evidenced by higher survival
Mingzhao Luo, Chengjie Xu, Wenjing Yang, Wensi Tang, Kai Chen, Jiaqing Guo, Qiyu Wang, Jun Chen, Zhaoshi Xu, Pierre Delaplace, Youzhi Ma, Yongbin Zhou, Ming Chen   +12 more
wiley   +2 more sources

Reduced task-related quadriceps sEMG and limited functional transfer after 4-week low-load blood flow restriction training: a pilot randomized controlled study [PDF]

Frontiers in Physiology
BackgroundLow-load blood-flow restriction training (BFR-LIR) can enhance strength-related adaptations with reduced mechanical stress, but whether it promotes task-related neuromuscular economy (lower task-related sEMG amplitude for comparable mechanical ...
Junwei Xia, Wonil Son, Tianqi Zhao, Ji-Kwang Ryu   +3 more
doaj   +2 more sources

Patterns of Autonomous and Conditional Neural Specification for the Brain and Ventral Nerve Cord in Annelida [PDF]

Evolution &Development, Volume 28, Issue 3, September 2026.
Diagrams of blastomere isolations in Capitella teleta and Platynereis dumerilii showing autonomous head neural tissue (from 1q) and trunk neural tissue (from 2d) as well as a decoupling of D–V axis formation from trunk neural tissue in annelids. ABSTRACT Evolution of central nervous systems is a long‐debated topic.
Nicole B. Webster, Johnny A. Davila‐Sandoval, Allan M. Carrillo‐Baltodano, Skyler Duda, B. Duygu Özpolat, Néva P. Meyer   +5 more
wiley   +2 more sources

Protective anti-fibrotic effect of liraglutide and Pirfenidone combination therapy on liver fibrosis in rats: effects on autophagy and NLRP3 inflammasome [PDF]

BMC Gastroenterology
Background Liver fibrosis is a significant complication of chronic liver diseases. While Pirfenidone (PFD) and Liraglutide (LIR) have shown promise individually in treating fibrosis, their combined effect on autophagy and NLRP3 inflammasome pathways ...
Zeynab Yousefi, Rayan Rajabi, Saeed Karima, Mitra Nourbakhsh, Abbas Sahebghadam Lotfi   +4 more
doaj   +2 more sources

Ameliorative Impact of Liraglutide on Chronic Intermittent Hypoxia-Induced Atrial Remodeling

Journal of Immunology Research, 2022
Atrial fibrillation (AF) is the most frequent form of clinical cardiac arrhythmias. Previous evidence proved that atrial anatomical remodeling (AAR) and atrial electrical remodeling (AER) are crucial for the progression and maintenance of AF.
Jun Wang, Yongzheng Liu, Changhui Ma, Yue Zhang, Meng Yuan, Guangping Li   +5 more
doaj   +1 more source

Role of SEC62 in ER maintenance: A link with ER stress tolerance in SEC62-overexpressing tumors?

Molecular & Cellular Oncology, 2017
Amplification of the candidate oncogene TLOC1/SEC62 in tumors correlates with reduced patient survival. The recently reported role of SEC62 as an autophagy receptor that controls endoplasmic reticulum (ER) size and function might open new scenarios for ...
Timothy J. Bergmann, Fiorenza Fumagalli, Marisa Loi, Maurizio Molinari   +3 more
doaj   +1 more source

Preparation of Lir@BSA-PMF nanoparticles and verification of their cell functions [PDF]

Jichu yixue yu linchuang
Objective To synthesize bovine serum albumin(BSA)-loaded liraqlutide (Lir)-nanoparticles coated with platelet membrane fragments (PMF) using a“bottom-up” nano-engineering chemistry technique, and to evaluate their cyto-compatibility and potential ...
HUANG Qingyu, CHEN Qiying, SUN Shengjia, WU Bangwei, LIN Shan, Alimujiang·MAIMAITIJIANG
doaj   +1 more source

Notch signaling is involved in the antiapoptotic effects of liraglutide on rat H9c2 cardiomyocytes exposed to hypoxia followed by reoxygenation

Journal of International Medical Research, 2020
Objective Liraglutide (Lir) protects cardiomyocytes against high glucose-induced myocardial damage. This study investigated whether Notch signaling participated in the antiapoptotic effects of Lir on rat H9c2 cardiomyocytes subjected to hypoxia followed ...
Juan Wu, Fei Xie, Yali Qin, Jie Liu, Zihua Yang   +4 more
doaj   +1 more source