Results 111 to 120 of about 13,805 (257)

A computational study of the mechanisms of growth-driven folding patterns on shells, with application to the developing brain

, 2017
We consider the mechanisms by which folds, or sulci (troughs) and gyri (crests), develop in the brain. This feature, common to many gyrencephalic species including humans, has attracted recent attention from soft matter physicists.
Garikipati, K., Verner, S. N.
core   +1 more source

The α-Tubulin gene TUBA1A in Brain Development: A Key Ingredient in the Neuronal Isotype Blend

Journal of Developmental Biology, 2017
Microtubules are dynamic cytoskeletal polymers that mediate numerous, essential functions such as axon and dendrite growth and neuron migration throughout brain development.
Jayne Aiken, Georgia Buscaglia, Emily A. Bates, Jeffrey K. Moore   +3 more
doaj   +1 more source

Miller–Dieker Syndrome Associated with Congenital Lobar Emphysema

American Journal of Perinatology Reports, 2014
Miller–Dieker syndrome (MDS) is a rare genetic syndrome associated with lissencephaly, developmental delay, and high mortality. We describe a patient who was diagnosed postnatally with both MDS and congenital lobar emphysema.
Linda Mahgoub, Khalid Aziz, Dawn Davies, Norma Leonard   +3 more
doaj   +1 more source

Association analysis of two single-nucleotide polymorphisms of the RELN gene with autism in the South African population [PDF]

, 2013
BACKGROUND: Autism (MIM209850) is a neurodevelopmental disorder characterized by a triad of impairments, namely impairment in social interaction, impaired communication skills, and restrictive and repetitive behavior.
Alcantara S, American Psychiatric Association, Bauman ML, Goffinet AM, Hajirah Gameeldien, Jyoti Rajan Sharma, Kanner L, Lize van der Merwe, Mandeep Kaur, Muneera Davids, Pickles A, Schopler E, Tissir F, Zainunisha Arieff   +13 more
core   +1 more source

Chromosomal map of human brain malformations [PDF]

, 2018
The etiology of most central nervous system (CNS) malformations remains unknown. We have utilized the fact that autosomal chromosome aberrations are commonly associated with CNS malformations to identify new causative gene loci.
Lurie, Iosif, Schinzel, Albert, Tyshchenko, Nataliya   +2 more
core  

Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice [PDF]

, 2009
Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis.
Abel, M.H., Baker, P.J., Huhtaniemi, I., Morris, I.D., O'Shaughnessy, P.J.   +4 more
core   +1 more source

Nestin selectively facilitates the phosphorylation of the Lissencephaly-linked protein doublecortin (DCX) by cdk5/p35 to regulate growth cone morphology and Sema3a sensitivity in developing neurons

bioRxiv, 2019
Nestin, an intermediate filament protein widely used as a marker of neural progenitors, was recently found to be expressed transiently in developing cortical neurons in culture and in developing mouse cortex.
C. J. Bott, Jason M. Keil, L. McMahon, C. Yap, Kenneth Y. Kwan, B. Winckler   +5 more
semanticscholar   +1 more source

Fetal and neonatal MRI features of ARX-related lissencephaly presenting with neonatal refractory seizure disorder.

Quantitative Imaging in Medicine and Surgery, 2019
Classification systems for congenital brain malformations are usually based on the stage of brain development when these abnormalities occur, hence we commonly recognize malformations as the result of disorders of cell proliferation, neuronal migration ...
S. ffrench-Constant, C. Kachramanoglou, B. Jones, N. Basheer, N. Syrmos, M. Ganau, W. Jan   +6 more
semanticscholar   +1 more source

Microcephaly [PDF]

, 2009
This issue of eMedRef provides information to clinicians on the pathophysiology, diagnosis, and therapeutics of ...
Michels, Thomas C., Morris, Monica, Myers, Tammy   +2 more
core  

Reducing Lissencephaly-1 levels augments mitochondrial transport and has a protective effect in adult Drosophila neurons

Journal of Cell Science, 2016
Defective transport of mitochondria in axons is implicated in the pathogenesis of several age-associated neurodegenerative diseases. However, the regulation and function of axonal mitochondrial motility during normal ageing is poorly understood. Here, we
Alessio Vagnoni, Patrick C. Hoffmann, S. Bullock   +2 more
semanticscholar   +1 more source