Results 61 to 70 of about 1,704,319 (230)
Research Directions on AI and Nuclear [PDF]
EPJ Web of ConferencesThe development of applications and systems for the nuclear domain involves the interplay of many different disciplines and is, therefore, particularly complex.
Cancila Daniela +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
“Lars von Trier was in the air”
ItinérairesIn 1995, the publication of the Dogma95 manifesto by Danish directors Lars von Trier and Thomas Vinterberg did not leave the graphic design community indifferent.
Léonore Conte
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Designing a General-Purpose 8-bit (T)FHE Processor Abstraction
Transactions on Cryptographic Hardware and Embedded SystemsMaking the most of TFHE programmable bootstrapping to evaluate functions or operators otherwise challenging to perform with only the native addition and multiplication of the scheme is a very active line of research.
Daphné Trama +4 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Comparative analysis of automatic radionuclide identification in γ-ray spectrometry: Machine learning versus statistical approaches [PDF]
EPJ Web of ConferencesGamma-ray spectrometry is a widely used technique for identifying and quantifying γ-emitting radionuclides in many nuclear applications. Currently, there is a growing trend to address the problem of automatic identification of radionuclides by ...
Phan Dinh Triem +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source