Results 71 to 80 of about 8,759,985 (270)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Judgment aggregation without full rationality [PDF]

open access: yes
Several recent results on the aggregation of judgments over logically connected propositions show that, under certain conditions, dictatorships are the only independent (i.e., propositionwise) aggregation rules generating fully rational (i.e., complete ...
Dietrich, Franz, List, Christian
core   +4 more sources

Neoclassical Theory Versus Prospect Theory: Evidence from the Marketplace [PDF]

open access: yes
Neoclassical theory postulates that preferences between two goods are independent of the consumer's current entitlements. Several experimental studies have recently provided strong evidence that this basic independence assumption, which is used in most ...
John A. List
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Research Directions on AI and Nuclear [PDF]

open access: yesEPJ Web of Conferences
The development of applications and systems for the nuclear domain involves the interplay of many different disciplines and is, therefore, particularly complex.
Cancila Daniela   +5 more
doaj   +1 more source

A reason-based theory of rational choice [PDF]

open access: yes
The standard rational choice paradigm explains an individual’s preferences by his beliefs and his fundamental desires. For instance, someone’s preference for joining the army might be explained by certain beliefs about what life in the army is like and a
Dietrich Franz, List Christian
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Opinion pooling on general agendas [PDF]

open access: yes
We consider the classical problem of opinion pooling: the probability assignments of different individuals are to be merged into collective probability assignments. While opinion pooling has been explored in some depth in the literature (by statisticians,
Dietrich, Franz, List, Christian
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Substitutability, Experience, and the Value Disparity: Evidence from the Marketplace [PDF]

open access: yes
Recent empirical evidence suggests that important disparities exist between willingness to pay and compensation demanded for the same good. These results, which clearly contradict closely held economic doctrines, have led some influential commentators to
John A. List
core  

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