Results 81 to 90 of about 15,938 (213)

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

PRELID1 and VDAC3 Coordinate a Senescence‐Like State in Germinal Center B Cells to Promote IL‐7–Driven Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
Colorectal cancer is characterized by an immunosuppressive microenvironment that limits immunotherapy efficacy. We identify a senescence‐like state in germinal center B cells driven by the PRELID1–VDAC3 axis, which promotes IL‐7 secretion, alleviates CD8+ T‐cell exhaustion, and enhances antitumor immunity. Targeting this pathway improves responsiveness
Yuhan Liao, Huimeng Xu, Xinghua Zhuo, Shupeng Hu, Lanhui Huang, Zhe Hao, Jianxiong Chen, Yulu Wang, Jun Zhou   +8 more
wiley   +1 more source

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

Design and Optimization of Full‐Stokes Hyperspectro‐Polarimetric Encoding Metasurfaces Based on Conditional Multi‐Task Deep Learning

Advanced Science, EarlyView.
A conditional multi‐task deep learning framework is developed for designing and optimizing Full‐Stokes Hyperspectro‐Polarimetric Encoding Metasurfaces (FHPEMs). This framework achieves joint spectro‐polarimetric learning and unified forward–inverse design.
Chenjie Gong, Haodong Shi, Qi Wang, Yingchao Li, Hongyu Sun, Jiayu Wang, Guanlin Li, Jian Zhang, Qiang Fu, Huilin Jiang   +9 more
wiley   +1 more source

Sub‐Unit‐Cell Logic Governs Transport in TPMS Architectures

Advanced Science, EarlyView.
ABSTRACT Next‐generation energy, thermal, and chemical systems require architectures capable of highly efficient transport across multiple length scales. Triply periodic minimal surfaces (TPMS), first conceptualized in 1865, offer inherently scalable geometries with exceptional transport potential, yet mechanistic links between topology and performance
Haozhang Zhong, Yipei He, Jiaxuan Wang, Chenyi Qian, Gerd E Schröder‐Turk, Raj Das, Junye Shi, Qi Tang, Zheda Ning, Wenjue Yi, Chuanwei Li, Jiangping Chen, Zeyao Chen, Binbin Yu, Jian LU, Jianfeng Gu, Ma Qian   +16 more
wiley   +1 more source

Redefining the Health Risk of Battery Materials Through a Biologically Transformed Metal Mixture

Advanced Science, EarlyView.
Inhaled NCM particles undergo lysosomal degradation, releasing complex ion mixtures that induce systemic impact. The impact is determined by a critical balance between antagonistic Ni‐Co interactions and synergistic Mn effects. To capture these complexities in risk assessment, we develop an IAI model, ensuring a more accurate quantitative risk ...
Ze Zhang, Gan Miao, Xueyu Zhang, Zhao Shu, Dawei Lu, Yujie Song, Shanfa Yu, Qian Liu, Yang Song, Rong Zhang, Xiaoting Jin, Yuxin Zheng   +11 more
wiley   +1 more source

Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease

Advanced Science, EarlyView.
This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang, Yuting Liu, Shufan Jiang, Zilin Fang, Mengda Jiang, Xiaofeng Tao, Tianyi Zhu, Jipeng Li, Sijie Fang, Xuefei Song, Yinwei Li, Jing Sun, Chuanjun Tong, Zhengrun Gao, Huifang Zhou, Xianqun Fan   +15 more
wiley   +1 more source

Design of Optical Transducer for Recognition of Biomolecular Interactions between Bacterial Lipopolysaccharides and Amino Acids

Advanced Science, EarlyView.
A deep comprehension of biomolecular phenomena at interfaces is significant with their fundamental and practical importance. Our experimental and theoretical investigations reveal that specific amino acids (glutamic acid and aspartic acid) exhibit an orientational coupling with liquid crystals, which can recognize and optically report the interfacial ...
Yena Choi, Sangmin Lee, Jin‐Kang Choi, Hyunsoo Han, Yeongseon Choi, Jun‐Hyung Im, Hyein Kim, Sangmin Jeon, Minjae Lee, Chang Yun Son, Young‐Ki Kim   +10 more
wiley   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source