Results 41 to 50 of about 14,164 (226)
أبعاد الفهم العميق اللازم تضمينها في كتب العلوم المطورة بالمرحله الإبتدائية [PDF]
مجلة العلوم التربوية - کلية التربية بقناالمستخلص: هدف البحث إلي التعرف علي أبعاد الفهم العميق اللازم تضمينها في كتب العلوم المطورة بالمرحلة الإبتدائية, وقد استخدم الباحث المنهج الوصفي لتحقيق هدف البحث , حيث تم الوصول إلي قائمة أبعاد العميق ومؤشراته من خلال مراجعة الأدبيات والدراسات ...
محمود عبد الراضي زكي محمود +2 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
معايير تصميم بيئات التعلم الإلکتروني المتنقل لتنمية مهارات برمجة صفحات الويب التعليمية [PDF]
تکنولوجیا التعلیم: سلسلة دراسات و بحوث, 2018 يهدف البحث الحالي إلى تطوير قائمة معايير الجودة لتصميم بيئات التعلم الإلکتروني المتنقل لتنمية مهارات برمجة صفحات الويب التعليمية لدى طلاب المرحلة الثانوية، واستخدم الباحثون المنهج الوصفي التحليلي في عرض واستخلاص المعايير من الأدبيات والدراسات المرتبطة ...
طاهر عبد الله فرحات +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
List of referees for year 2017 / Список рецензетов за 2017. год / Spisak recenzenata za 2017. godinu
Vojnotehnički Glasnik, 2017 All submitted manuscripts relevant to the journal’s profile are reviewed. All referees are eminent experts in relevant fields, with papers published in these fields in the last three years. Editorial Board applies the iThenticate (CrossRef and CrossCheck)
Nebojša N. Gaćeša
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source