Results 91 to 100 of about 430,620 (307)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
, 2012 Romanticism and Contemporary Criticism (Morris Eaves and Michael Fischer) (Reviewed by Marcel Cornis-Pop, University of Northern Iowa)Contemporary Literary Criticism: Modernism Through Post-Structuralism (Robert Con Davis) (Reviewed by Thomas McLaughlin,
Editors, Criticism
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
BRAZILIAN LITERARY CRITICISM AND HISTORIOGRAPHY
Revista Brasileira de Literatura Comparada, 2020 In Brazil literary studies, after scant manifestations in the colonial period, represented by the activity of literary academies founded in the 18th century only really expanded in the course of the 19th century.
Roberto Acízelo de Souza +1 more
doaj
[Review of] Gina Marchetti. Romance mId the Yellow Peril: Race, Sex, and Discursive Strategies in Hollywood Fiction [PDF]
, 1994 Marchetti poignantly mirrors Orientalism as conceived in the eyes of typical Hollywood filmmakers of their Eurocentric discourse, flavored with their own notions of romance, race and sexuality, and the Yellow Peril, the way they want to entertain the ...
Kim, Eugene C.
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Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
On the method of analyzing the “nature-text” in ethical literary criticism
НеофилологияINTRODUCTION. The application of the method of “text-nature” analysis is discussed, based on the concept of “umwelt”, which is of decisive importance for ethical literary criticism.
Yao Tingting, Ye Lin
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