Results 41 to 50 of about 48,547 (300)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Quo virtus?: the concept of propriety in ancient literary criticism
, 1987 The standard of propriety is frequently appealed to in ancient literary discourse, most notably in discussions of poetics, criticism of literary works and precepts for composition.
DeWitt, H. M. +2 more
core +1 more source
Literary criticism must be scientific
Sign Systems Studies, 2022 Literary criticism must be ...
Juri Lotman
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Literary criticism as RPG [PDF]
Slovenska Literatura, 2011 The study is a part of a more extensive work which deals with seeing literature as a competetive game and individual communication strategies used by the participants of the game, that is literature experts. From this point of view the role of a literary
Pavel Janoušek
doaj
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
A new approach to literary theory and criticism [PDF]
, 2014 Literary theory is a systematic study of the nature of literature and of the methods for analyzing literature. Literary theory and literary criticism are interpretative tools that enable us to think insightfully about the literature we read.
Malik, R. S., Batra, Jagdish
core
Social and cultural meaning of literary criticism: Addendum to theoretical discussion on the literary criticism notion and its being [PDF]
Baština, 2015 The paper aims to define the literary criticism notion and its being within the historical chronotope. The literary criticism has a two-way approach to a work of art: internal and external.
Mumović Ana Đ.
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source