Results 61 to 70 of about 427,886 (291)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Critical execution : examination of The Virginian and Riders of the purple sage as formula westerns : an honors thesis (HONRS 499) [PDF]
, 1993 This discussion of the critical approaches to popular fiction, specifically, Owen Wister's The Virginian and Zane Grey's Riders of the Purple Sage is intended to point out the short-comings of traditional literary criticism in popular fiction and ...
Fisher, Travis E.
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
La critique littéraire de Maurice Nadeau dans France-Observateur en 1954
ContextesThe 1950s were a time of transition both in literary and critical terms. Maurice Nadeau, editor and critic, notably through his literary columns in France-Observateur, was both an actor and a witness to this move towards a New Criticism and towards a ...
Élodie Chevreux
doaj +1 more source
Meta-composition and literary criticism on the Persius’ first satire
Cadernos de Letras da UFF, 2018 The comic traces that lead to questionings and criticism had always been part of the Roman soul. Nevertheless, literary criticism would be enforced only within the genres born from the Hellenistic influence that was growing since the fall of the Republic.
Lucas Amaya
doaj +1 more source
New Perceptions: Kinugasa Teinosuke\u27s Films And Japanese Modernism [PDF]
, 2004 This essay offers a reading of Kinugasa Teinosuke\u27s independent silent films as responses to the traumatic experience of twentieth-century modernity. Of particular interest are the global and local intertexts in A Page of Madness and Crossways, their ...
Gardner, William O.
core +1 more source
Plotting Devices: Literary Darwinism in the Laboratory
, 2014 Critics of literary Darwinism like to point out the weaknesses of its scientific scaffolding, but the real flaw in this research program is its neglect of literary history and stylistic evolution.
Hay, John
core +1 more source
The category of comparison in literary criticism [PDF]
, 2015 Celem artykułu jest próba odpowiedzi na kilka pytań związanych z zastosowaniem porównania w tej szczególnej dziedzinie literaturoznawstwa, jaką stanowi krytyka literacka.
Puchalska, Iwona
core +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source