Results 31 to 40 of about 4,440,395 (350)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

British India and Victorian literary culture [PDF]

, 2015
British India and Victorian Culture extends current scholarship on the Victorian period with a wide-ranging and innovative analysis of the literature of British India.
ní Fhlathúin, Máire, Máire ní Fhlathúin, n� Fhlath�in, M�ire   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Literary Hispanophobia and Hispanophilia in Britain and the Low Countries (1550-1850) [PDF]

, 2020
Spain has been a fruitful locus for the European imagination for centuries, and it has been most often perceived in black-and-white oppositions -- either as a tyrannical and fanatical force in the early modern period or as an imaginary geography of a ...

core   +2 more sources

Philosophical Perspectives on Tove Jansson’s "Moominsummer Madness" through Walter Benjamin’s Ideas of Play

Zagadnienia Rodzajów Literackich
This study examines philosophical perspectives in Tove Jansson’s Moomin novel Moominsummer Madness (MM, 2010 [1954]), with particular attention to the theatrical performance embedded in the narrative. These perspectives are informed by Walter Benjamin’s
Pirjo Suvilehto, Jarosław Płuciennik
doaj   +1 more source

Cultural Literary Landscapes

Crossings: An Undergraduate Arts Journal, 2023
"Challenging Cultural Literary Landscapes: Poetry as Mediation, Experience, and Myth” was originally written for an Italian special topics course on the experiences of Italian-Canadians. This essay covers the Italian diaspora’s representation in Canadian literature with a concentration on the depiction of ethnicity, race, and culture.
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Haunted Sketches: Analyzing the Foundations of Horror in Early Works by Tove Jansson and Walt Disney

Zagadnienia Rodzajów Literackich
This article explores the early artistic influences and beginnings of Tove Jansson and Walt Disney, focusing on their works’ gothic and surreal elements. Both Jansson and Disney are renowned for their contributions to children’s entertainment, yet their
Jarosław Płuciennik, Pirjo Suvilehto
doaj   +1 more source

French Literary Fascism: Nationalism, Anti-Semitism, and the Ideology of Culture by Jewel Spears Brooker (review)

, 2016
AcknowledgmentsIntroduction: Literature, Culture, Fascism3Pt. 1The Fathers of French Literary Fascism171The Use and Abuse of Culture: Maurice Barres and the Ideology of the Collective Subject19The Cult of the Self19Cultural and Racial Typologies27The ...
Patricia D. Hopkins
semanticscholar   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source