Results 31 to 40 of about 677,580 (311)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cultural ecology and Chinese Hamlets [PDF]
, 2011 This essay examines the critical potential of cultural ecology and cultural mobility studies for modeling the relations between literature and culture. It investigates the mobility and portability of literary effects across different media, periods, and ...
Berensmeyer, Ingo
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Crossings: An Undergraduate Arts Journal, 2023 "Challenging Cultural Literary Landscapes: Poetry as Mediation, Experience, and Myth” was originally written for an Italian special topics course on the experiences of Italian-Canadians. This essay covers the Italian diaspora’s representation in Canadian literature with a concentration on the depiction of ethnicity, race, and culture.
openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
, 2016 A review of Smith, Mark S. Poetic Heroes: Literary Commemorations of Warriors and Warrior Culture in the Early Biblical World. Grand Rapids, MI: Eerdmans, 2014. xxiv1636 pp. $55.00 (paper)
Doak, Brian R.
core +2 more sources
Nilai Budaya Lokal dalam Cerpen Warung “Penajem” dan Relevansinya dalam Pengajaran Sastra di Perguruan Tinggi [PDF]
, 2017 Rapid modernization may step the local culture down unwittingly. Without a strong defense, that local culture will be eroded and disappeared sooner or later. The efforts are needed to keep the local culture and make it more recognizable to the world.
Hapsari, T. P. (Theresia)
core +5 more sources
'Languishing from a distance': Louis Meyer and the demise of the German Jewish ideal [PDF]
, 2014 Louis Meyer (1796-1869), a Polish-Jewish merchant living in the middle-sized Polish provincial town of Wloclawek, authored a broad range of literary works in the German language.
Guesnet, F
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Haunted Sketches: Analyzing the Foundations of Horror in Early Works by Tove Jansson and Walt Disney
Zagadnienia Rodzajów LiterackichThis article explores the early artistic influences and beginnings of Tove Jansson and Walt Disney, focusing on their works’ gothic and surreal elements. Both Jansson and Disney are renowned for their contributions to children’s entertainment, yet their
Jarosław Płuciennik, Pirjo Suvilehto
doaj +1 more source