Results 41 to 50 of about 4,440,395 (350)

Scottish Medicine and Literary Culture, 1726-1832

open access: yes, 2014
Scottish Medicine and Literary Culture, 1726–1832 examines the ramifications of Scottish medicine for literary culture within Scotland, throughout Britain, and across the transatlantic world.

core   +1 more source

TRANSFORMATION OF LITERARY CULTURE IN RUSSIA

open access: yesSOCIETY AND SECURITY INSIGHTS, 2018
The article presents the results of an empirical study of the literary culture of modern Russia. The relevance of the study is due, on the one hand, to the importance of literature as an institution for the reproduction of culture and the channel of social communication, and on the other hand, to a significant change in its role and forms of ...
openaire   +3 more sources

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Rhetorical Analysis of Literary Culture in Social Reading Platforms

open access: yes, 2013
In their article "Rhetorical Analysis of Literary Culture in Social Reading Platforms" Joachim Vlieghe and Kris Rutten present a case study of the discourse surrounding literary phenomena that are emerging within social media. The case study is part of a
Joachim Vlieghe, K. Rutten
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

The Literary Cultures of the Scottish Reformation

open access: yesThe Review of English Studies, 2006
Throughout the twentieth century Scottish literary studies was dominated by a critical consensus, engineered by Edwin Muir and Hugh MacDiarmid, which addressed the anti-Catholic atmosphere of early twentieth-century Scotland by rereading the reformation.
openaire   +2 more sources

Contemporary Australian Literary Culture

open access: yes, 2017
Contemporary Australian literary culture is formed through networks of institutions that support writing and reading. This infrastructure, itself shaped by Australia’s history as a former British colony and its current status as a medium-sized market in ...
Beth Driscoll
core   +1 more source

Literary Prize Cultures: A Fairer Future?

open access: yes, 2023
In June 2022, Costa Coffee announced that they would no longer be running the Costa Book Awards, one of the UK's most significant series of awards for fiction, children's books, poetry, non-fiction, and short fiction.
Marsden, Stevie
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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