Results 101 to 110 of about 5,429,905 (405)

Shakespeare Burlesque and the Performing Self [PDF]

open access: yes, 2012
This paper argues that Victorian Shakespeare burlesques reveal an alternate literary history: a movement away from private, novelistic consciousness toward collaborative performance.
Pollack-Pelzner, Daniel
core   +1 more source

Plotting Devices: Literary Darwinism in the Laboratory

open access: yes, 2014
Critics of literary Darwinism like to point out the weaknesses of its scientific scaffolding, but the real flaw in this research program is its neglect of literary history and stylistic evolution.
Hay, John
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Yes David, it is : a response to David Perkins' work, Is literary history possible? : an honors thesis (HONRS 499) [PDF]

open access: yes, 1999
Yes David, It Is was inspired by Is Literary History Possible?, a text by David Perkins that presents factors that Perkins' asserts make the writing of literary history an impossible task Yes David, It Is is a response to Perkins' work that offers ...
Peterson, Krista S.
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

He Was The Best of Kings; He Was the Worst of Kings: A Critique of the Literary Presentation of Richard I

open access: yes, 2015
In order to achieve a more holistic understanding of Mediterranean History during the Third Crusade, a critical analysis of Richard I is necessary. This paper questions how accurately Richard I was portrayed in literary sources during the Third Crusade ...
Reed, Estelle
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Augustin Buzura’s Orgolii: on the “faces” of Romanian communism [PDF]

open access: yesDiversitate si Identitate Culturala in Europa
This study aims to demonstrate that Romanian novelists of the 1960s unveil both the terror of the Dej regime and the more sophisticated methods of torture employed under Ceaușescu.
Ana-Maria BĂNICĂ
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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