Results 71 to 80 of about 836,141 (310)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Rethinking the History of the Literary Symposium [PDF]
, 1992 published or submitted for ...
Greek Seminar 420 Spring 1992 UIUC +1 more
core
You No Real Man : Constructing Gender, Sexuality, and the Asian American Subject in Jana Monji\u27s Kim [PDF]
, 2013 Jana Monji\u27s short story Kim offers a stunning plot twist that challenges readers initial interpretations of the characters as well as many assumptions and stereotypes about Asian American identity, gender, sexuality, and culture.
Field, Robin E.
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
The Sickle and the Piano. A Distant Reading of Work in the Nineteenth Century Romanian Novel
Metacritic Journal for Comparative Studies and Theory, 2020 This article conducts a semantic search of The Digital Museum of the Romanian Novel: The 19th Century (MDRR), through which the authors attempt to identify the occurrences of several key concepts for class and labour imagery in the nineteenth-century ...
Ștefan Baghiu, Cosmin Borza
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Literary Histories and Literary Futures:
Crossings: A Journal of English Studies, 2015 The debate between authors who write in English and those who write in the South Asian vernaculars – or bhashas – is well known in South Asian literary studies. The debate is not only about language, but about a writer’s desired audience and her commitment (or lack thereof) to cosmopolitanism on one hand and nationalism on the other.
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source