Results 91 to 100 of about 597,924 (360)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Jumpstarting the future with Fredric Jameson: Reflections on capitalism, science fiction and Utopia [PDF]
, 2009 This paper turns around the key concern that it has become almost impossible to imagine a form of the future that is neither a prolongation of what already exists nor its apocalyptic demise.
De Cock, CJL
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Some problems of writing historiography in Southern Africa
Literator, 1989 In this article, the author has come to the conclusion that the established literary definitions no longer serve to define the nature of the South African literary system, and that current literary criteria are no longer functional in determining the ...
S. Gray
doaj +1 more source
The Literary Presentation of Science [PDF]
Nature, 1961 The Craft of Technical Writing By Daniel Marder. Pp. xiv + 400. (New York and London: The Macmillan Company, New York, 1960.) 35s.
openaire +1 more source
History, Literature, and Authority in International Law [PDF]
, 2018 One consequence of international law’s recent historical turn has been to sharpen methodological contrasts between intellectual history and international law. Scholars including Antony Anghie, Anne Orford, Rose Parfitt, and Martti Koskenniemi have taken
Christopher Warren
core +1 more source