Results 101 to 110 of about 593,895 (358)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Some problems of writing historiography in Southern Africa

open access: yesLiterator, 1989
In this article, the author has come to the conclusion that the established literary definitions no longer serve to define the nature of the South African literary system, and that current literary criteria are no longer functional in determining the ...
S. Gray
doaj   +1 more source

The Literary Presentation of Science [PDF]

open access: yesNature, 1961
The Craft of Technical Writing By Daniel Marder. Pp. xiv + 400. (New York and London: The Macmillan Company, New York, 1960.) 35s.
openaire   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Primary school, science, and scientific literary [PDF]

open access: yesJournal of Chemical Education, 1983
Education can be imagined as a series of human experiences that supplement and reinforce each other to provide the depth and breadth of knowledge that are necessary to deal with, and contribute to, the details of living in a technological society. Primary school is a key component in the development of a modern, technologically-based society, so why is
openaire   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Quantifying origin and character of long-range correlations in narrative texts

open access: yes, 2015
In natural language using short sentences is considered efficient for communication. However, a text composed exclusively of such sentences looks technical and reads boring.
Bazarnik, Katarzyna   +7 more
core   +1 more source

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