Results 131 to 140 of about 804,700 (317)

English Literary Studies

open access: yesAmerican Journal of Islam and Society, 2014
On January 15, 2014, Md. Mahmudul Hasan, assistant professor in the Departmentof English Language and Literature at the International Islamic UniversityMalaysia, addressed an audience at the IIIT headquarters in Herndon,VA. He spoke on how Muslims have tended to associate English studies withwestern value systems, secularism, and anti-Islamic practices.
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Contexts and pragmatic strategies of COVID-19 related cartoons in Nigeria

open access: yesLanguage and Semiotic Studies
The global outbreak of the coronavirus pandemic has been experienced differently by people depending on their socio-cultural contexts. These varied experiences are expressed in various forms of communication, including cartoons.
Olajimbiti Ezekiel Opeyemi   +1 more
doaj   +1 more source

[Review of] Carl Gutierrez-Jones. Rethinking the Borderlands: Between Chicano Culture and Legal Discourse [PDF]

open access: yes, 1995
In this ambitious book, Carl Gutierrez-Jones musters ideas from Critical Race Studies, Critical Legal Studies, and literary scholarship to explicate the relationship between Chicanos and the law.
Goldstein-Shirley, David
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

The image of a writer in nobel lectures delivered by laureates in literature [PDF]

open access: yes, 2018
Background. A growing interest in discursive nature of Nobel lectures resulted in a number of studies which emphasize their rhetorical force to influence public opinion and to popularize ideas in different spheres of human life.
Pavlenko, Larysa
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

[Review of] Manuel de Jesus Hemandez-Gutierrez and David William Foster, eds. Literatura Chicana, 1965-1995: An Anthology in Spanish, English, and Calo [PDF]

open access: yes, 1997
The works included in this anthology, many of them previously printed, reflect six characteristic themes of Chicana/o contemporary literature: the search for identity, feminism, conservatism, revisionism, homoeroticism, and internationalism (xix ...
Kafka, Phillipa
core   +1 more source

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