Results 61 to 70 of about 118,624 (316)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Language and Communication Implications of Artificial Intelligence on Selected Nigerian University Undergraduates

open access: yesABUAD Journal of the Humanities-AGIDIGBO
In recent times, the emergence of artificial intelligence has had a tremendous influence on human language and communication. It involves developing computer programmes to complete tasks which would otherwise require human intelligence.
Jane Chinelo OBASI   +1 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

NAVIGATING SOLITARY CONFINEMENT IN RUTH FIRST’S 117 DAYS

open access: yesFilolog
Despite benefiting greatly from apartheid, a small number of white South Africans decided to join the war being waged by black South Africans because they were revolted and appalled by the system’s abuses.
Mobolanle Sotunsa   +1 more
doaj   +1 more source

The Linguistic Turn in Contemporary Japanese Literary Studies [PDF]

open access: yes, 2020
The 1970s and 1980s saw a revolution in Japanese literary criticism. A new generation of scholars and critics, many of them veterans of 1960s political activism, arose in revolt against the largely positivistic methodologies that had hitherto dominated ...

core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MULTIMODAL DISCOURSE ANALYSIS OF IDENTITY CONSTRUCTION IN SELECTED NIGERIAN MAGAZINE ADS

open access: yesFilolog
This study examines how multimodal elements in selected Nigerian magazine advertisements shape identity construction. Using purposive sampling, ten brand advertisements were selected from three Nigerian magazines, Accomplish Magazine, This Day Style and
Jane Chinelo Obasi, Doreen Chisom Eze
doaj   +1 more source

Australian Literature : Points for Departure

open access: yes, 1999
In the conclusion to her germinal study of sex, race and nation in Australian women's writing, Along the Faultlines (1995), Susan Sheridan questions the prevalent orientations of Australian and literary cultural studies. In particular she draws attention
Whitlock, Gillian
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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