Results 81 to 90 of about 827,412 (367)

Crossovers: Digitalization and literature in foreign language education [PDF]

open access: yes, 2019
Digitalization produces increasingly multimodal and interactive literary forms. A major challenge for foreign language education in adopting such forms lies in deconstructing discursive borders between literary education and digital education (romance of
Lütge, Christiane   +3 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Assessing Online Pronunciation Tutors For Improving L2 Learners English Problematic Phoneme

open access: yesThe Journal of Studies in Language, Culture and Society
This paper investigates the effectiveness of online pronunciation platforms in helping second language (L2) learners of English overcome difficulties with problematic phonemes, which are sounds that L2 learners often struggle to perceive and articulate.
Julianah Ajoke Akindele   +1 more
doaj  

The Internal Structure of Causal Subordinators and the Attachment Site of Causal Clauses in the History of Italian

open access: yesLanguages
This paper investigates the syntax and diachrony of Italian causal clauses introduced by perché, siccome, and poiché. Although often treated as near-synonyms in Contemporary Italian, these subordinators differ systematically in their syntactic ...
Jacopo Garzonio, Emanuela Sanfelici
doaj   +1 more source

Entrepreneurial Literary Theory: A Debate on Research and the Future of Academia [PDF]

open access: yes, 2017
Across the world at present, researchers and teachers are being exhorted to become entrepreneurial. Universities are being restructured accordingly. The debate presented in this book considers what that involves and portends for academia.
Durao, Fabio A.   +3 more
core  

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

open access: yes
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana   +8 more
wiley   +1 more source

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