Results 71 to 80 of about 17,514 (260)

Una modesta proposta per gli studi letterari

CoSMO, 2013
The essay examines the current status of literary studies and critical analysis. Reassessing the intellectual tradition within the humanities, the Author discusses the significance of literature, narratology and semiotics to other disciplines.
Rosamaria Loretelli
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Las corrientes de investigación en teoría de lo fantástico presentes en el hispanismo: estado de la cuestión

Studia Romanica Posnaniensia, 2013
Tzvetan Todorov typified the literary fantastic as an autonomous gender in 1970, separating it from marvelous texts and other bordering modes that contained unreal or supernatural elements.
Alfons Gregori
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Las escritoras y su mediación del conocimiento científico: otra manera de aproximarse a los archivos de poetisas chilenas (1870-1910).

Cuadernos LIRICO
This paper studies the role of Chilean women poets as mediators of scientific knowledge in newspapers of the late nineteenth and early twentieth centuries. It proposes another way of understanding poetry, as a tool for the diffusion of science, and along
Verónica Ramírez Errázuriz
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Wali Ahmadi. « Exclusionary Poetics: Approaches to the Afghan ‘Other’ in Contemporary Iranian Literary Discourse ». Iranian Studies, vol. 37, n°3 (September 2004), pp. 407-429. [PDF]

Abstracta Iranica, 2006
Que reste-t-il de la grande aire culturelle persanophone transnationale de l’epoque classique ? A en croire les critiques iraniens contemporains, il semble que l’Iran seul a su adapter sa production litteraire aux exigences de la modernite, ce qui justifierait l’exclusion de la litterature persane non-iranienne, demeuree a un « stade infantile », du ...
openaire   +1 more source