Results 81 to 90 of about 17,514 (260)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

BRAZILIAN LITERARY CRITICISM AND HISTORIOGRAPHY

Revista Brasileira de Literatura Comparada
In Brazil literary studies, after scant manifestations in the colonial period, represented by the activity of literary academies founded in the 18th century only really expanded in the course of the 19th century.
Roberto Acízelo de Souza, José Luís Jobim   +1 more
doaj  

نحو أفق دراسة نسقيّة للظاهرة الأدبيّة و تاريخ الأدب

مجلة الآداب و العلوم الإجتماعية, 2016
During the recent years, researchers in cultural and literary studies have been increasingly making use of the accumulated knowledge (both theoretical and practical), aiming at widening the scope of literary studies to reach new horizons in the field of ...
خالد زيغمي
doaj  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Theory's other : reintegrating the new pragmatism into literary studies

, 2018
Perspektywa krytyczna, która pojawiła się w literaturoznawstwie amerykańskim na początku lat osiemdziesiątych dwudziestego wieku, kwestionuje potrzebę zajmowania się teorią jako taką, definiując jednak ową teorię w bardzo zawężony sposób. Neopragmatyzm, którego jaskrawym i bardzo spektakularnym przykładem jest esej Waltera Benna Michaelsa i Stevena ...
openaire   +4 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

NERVOUS SOUNDS: AUDITIVE ASPECTS IN AMERICAN CITY TEXTS

Известия Южного федерального университета: Филологические науки, 2009
The article deals with sounds and noises as a new field of studies. It is my intention to establish a link between Modernism as a period defined by literary and cultural history on the one hand and soundscape studies on the other.
R. Gunzenhaeuser
doaj   +2 more sources

Introduction to Special Issue: Literary Translingualism: Multilingual Identity and Creativity

L2 Journal, 2015
The guest editors introduce L2Journal readers to an emerging field of translingual literature--texts by authors using more than one language or a language other than their primary one.
Natasha Lvovich, Steven G Kellman
doaj  

Object-Books and Exposed Writings: New Textual and Literary Landscapes in Latin America and Spain

Anais do Museu Paulista: História e Cultura Material, 2020
In this essay I explore new ways of literary transmission edited in formats other than the codex in Latin America and Spain. My study also analyzes what Armando Petrucci called exposed writings.
Rafael Climent-Espino
doaj  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source