Results 61 to 70 of about 16,041 (265)
Vooys, 2004 Waarom literaire theorie? Om het specifieke van het fenomeen ‘literatuur’ ten opzichte van andere talige en culturele expressies in kaart te brengen. Vaak betreft het hier vragen waar men een antwoord op wil krijgen, bijvoorbeeld ‘wat is literatuur?’, ‘wat is de functie van literatuur’ en ‘aan welke behoeften kan of moet literatuur voldoen?’.
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
OD REDAKCJI: Queerowe konteksty literatury polskiej
Zagadnienia Rodzajów LiterackichThe text concerns the application of concepts and terms created within queer studies to a Polish context, especially in literary studies. The issue discussed by participants in the debate on the possibility of assimilating queer studies into the Polish ...
Agnieszka Izdebska
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Creativity Studies, 2012 Within the field of meaning (re)production, the newly fashioned media theories have been stemming from Marshall McLuhan's and Mikhail Bakhtin‘s “hybrids” and generating what we are presently experiencing as flexible theoretical phenomena, exposed to ...
Aida Elisabeta Osian
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
A Poética Sociológica de Medviédev e Sua Atualidade
MatLit, 2013 Review of Pável Nikoláievitch Medviédev. O método formal nos estudos literários: introdução crítica a uma poética sociológica, Trad. Ekaterina Vólkova Américo e Sheila Camargo Grillo, São Paulo, Contexto, 2012, 269 pp. [1ª ed., Leningrado, Pribói, 1928].
Matheus de Brito
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source