Results 51 to 60 of about 69,750 (309)

Tragedy [PDF]

open access: yes, 2019
From Plato’s Republic and Aristotle’s Poetics onwards, tragedy has loomed large in the genealogy of literary theory. But this prominence is in many regards paradoxical.
Toscano, Alberto, Alberto Toscano
core   +1 more source

Jacques Lacan (Pre-published version)

open access: yes, 2017
Jacques Marie Émile Lacan was born on April 13, 1901 and died on September 9 1981. He was a French psychoanalyst and philosopher and was a very controversial figure on the French psychoanalytic scene.

core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

“The case” of Poor Ioanide, or on critical reception in different stages of post-war Romanian literary history [PDF]

open access: yesDiversitate si Identitate Culturala in Europa
This article aims to present some aspects regarding the critical reception of the novel Bietul Ioanide, whose subject is set in the post-war period.
Ana-Maria BĂNICĂ
doaj  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

THE VALUE OF RELEVANCE THEORY IN LITERARY ANALYSIS [PDF]

open access: yes, 2011
Artikel ini mengkaji pandangan Formalist Linguistics dan Relevance Theory terhadap karya sastra. Formalist Linguistics berpandangan bahwa nilai sebuah karya sastra terletak pada keistimewaan bahasanya.
Candria, Mytha
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Bad mothers and maternal ambivalence in Ciclul Hallipilor [The Hallipa cycle] by Hortensia Papadat-Bengescu and Patimi [Passions] by Sofia Nădejde

open access: yesSwedish Journal of Romanian Studies
The article analyzes the symptomatic representations of maternal experience in the modern Romanian novel written by women. It aims to draw attention to maternal voices portrayed in literary texts across national contexts at the beginning of the 20th ...
Ioana Moroșan
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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