Results 51 to 60 of about 630,776 (307)
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
“The case” of Poor Ioanide, or on critical reception in different stages of post-war Romanian literary history [PDF]
Diversitate si Identitate Culturala in EuropaThis article aims to present some aspects regarding the critical reception of the novel Bietul Ioanide, whose subject is set in the post-war period.
Ana-Maria BĂNICĂ
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
How to spice up a breakfast cereal or The translation of culturally bound referential items in “The bluest eye” by Toni Morrison and “Vineland” by Thomas Pynchon [PDF]
, 2013 This article will attempt to suggest translation procedures necessary to translate culturally bound items in the referential level of a literary work illustrated with examples from two novels: “The Bluest Eye” by Toni Morrison and “Vineland” by Thomas ...
Barciński, Łukasz
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
A prophet in his country [PDF]
Diversitate si Identitate Culturala in Europa, 2018 This text is a tribute to the academician Eugen Simion, on his 85th birthday. A former president of the Romanian Academy (1998 – 2006), member of academic societies in France, Denmark, Moldova, university professor, literary critic and historian, editor,
Lucian CHIȘU
doaj
The Material and “Inner Life” in Music: Beethoven, Psychological Coherence, and Meaning
Humanities, 2015 Current studies on Adolph Bernhard Marx generally focus on Marx’s seminal texts in music theory and pedagogy, such as Die Lehre von der musikalischen Komposition, praktisch theoretisch (1837–1847) and Marx’s theory of sonata form, but they infrequently ...
Sara Eckerson
doaj +1 more source