Results 51 to 60 of about 16,041 (265)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

How Do We Read in the Age of Intertextual Digitalism?Bibliography and webography [PDF]

open access: yesDiversitate si Identitate Culturala in Europa
The study is a reflection about how reading practices, habits, attitudes and methods changed in the most recent context of digitalism. This type of digital globalization has many consequences on humanistic studies.
George NEAGOE
doaj  

The Material and “Inner Life” in Music: Beethoven, Psychological Coherence, and Meaning

open access: yesHumanities, 2015
Current studies on Adolph Bernhard Marx generally focus on Marx’s seminal texts in music theory and pedagogy, such as Die Lehre von der musikalischen Komposition, praktisch theoretisch (1837–1847) and Marx’s theory of sonata form, but they infrequently ...
Sara Eckerson
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Augustin Buzura’s Orgolii: on the “faces” of Romanian communism [PDF]

open access: yesDiversitate si Identitate Culturala in Europa
This study aims to demonstrate that Romanian novelists of the 1960s unveil both the terror of the Dej regime and the more sophisticated methods of torture employed under Ceaușescu.
Ana-Maria BĂNICĂ
doaj  

Stimmungen or "In the Mood for Differentiality"

open access: yesMatLit, 2014
Review of Hans Ulrich GUMBRECHT. Atmosphere, Mood, Stimmung: On a Hidden Potential of Literature, Trans. Erik Butler, Stanford, CA: Stanford University Press, 2012, pp. 148 [1st ed. Munich, Carl Hanser Verlag, 2011].
Matheus de Brito
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Syntactic Analyzability in Complex Predicates: Verbal Periphrases, Serial Verbs and Auxiliary Chains

open access: yesLanguages
This article examines the relationship between semantic and syntactic evolution in the development of three Spanish verbal constructions: verbal periphrases, pseudo-coordinative constructions (e.g., va y dice), and auxiliary chains.
Mar Garachana-Camarero
doaj   +1 more source

Mediações Dilaceradas: Linguagem e Experiência no Pensamento de Theodor Adorno

open access: yesMatLit, 2013
This article focuses on the concept of "mediation" as used by Adorno throughout his philosophical and critical work. Starting with his discussion about culture in contemporary society, the paper examines his reflections on language as a process lacerated
Matheus de Brito
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

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