Results 51 to 60 of about 36,289 (301)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

‘The Subversion of Dialects’: Changing Attitudes towards Rural Varieties of Galician

Languages
The gheada and the seseo are the two pronunciations most stigmatised by the top-down standardising tradition of Galician from the mid-19th century. Social stereotypes of peasantry, ignorance, and vulgarity were built on them.
Montserrat Recalde, Mauro Fernández
doaj   +1 more source

O nouă perspectivă asupra literaturii române din perioada postcomunistă. Mihai Iovănel, Istoria literaturii române contemporane: 1990–2020

Romanica Cracoviensia, 2022
New Perspective on Romanian Post-Communist Literature. Mihai Iovănel, History of Contemporary Romanian Literature: 1990–2020 The article addresses Mihai Iovănel’s 2021 History of Contemporary ...
Olga Bartosiewicz-Nikolaev
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Coste, Florent. 2024. L’ordinaire de la littérature. Que peut (encore) la théorie littéraire ? Paris: La Fabrique.

Compendium
Book review of Florent Coste, L’ordinaire de la littérature. Que peut (encore) la théorie littéraire ? Paris: La Fabrique, 2024. While analyzing the reasons for the decline of literary theory, the author explains the absolute necessity of literary ...
Jan Baetens
doaj   +1 more source

Reader-Response Theory and Approach: Application, Values and Significance for Students in Literature Courses

SEEU Review, 2019
This article discusses the implementation of the reader-response theory and approach in the context of a literature course (English Literature 1) taught to students enrolled at the Department of English Language and Literature, who are preparing to be ...
Spirovska Elena
doaj   +1 more source

How Literature Works: Poetry and the Phenomenology of Reader Response

Phenomenology & Practice, 2010
Reader response literary theory dominates the study of literature in the K -12 school curriculum. Because this theory reflects the student - centered, constructivist orientation currently driving curriculum development, reader response literary theory is
Patrick G. Howard
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Distant reading in literary studies: a methodology in quest of theory

Testo & Senso, 2021
Since Franco Moretti coined the successful term distant reading, quantitative/computational text analysis methods have gained wide circulation in literary studies.
Fabio Ciotti
doaj  

Reader-Response Theory and Literature Discussions: a Springboard for Exploring Literary Texts

The New Educational Review, 2019
Reader-response theory is based on the assumption that a literary work takes place in the mutual relationship between the reader and the text. According to this theory, the meaning is constructed through a transaction between the reader and the text ...
Ç. Mart
semanticscholar   +1 more source