Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
The forgotten first: John MacCormick's 'Dùn-Àluinn' [PDF]
, 2006 The first Gaelic novel, John MacCormick's Dùn-Àluinn, no an t-Oighre 'na Dhìobarach, was serialised in the People's Journal in 1910 before being published in its entirety in 1912.
Kidd, S.M.
core
Stabilizing switching signals: a transition from point-wise to asymptotic conditions
, 2017 Characterization of classes of switching signals that ensure stability of switched systems occupies a significant portion of the switched systems literature.
Chatterjee, Debasish, Kundu, Atreyee
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Lexico-semantic processing in individuals with Alzheimer’s disease: Evidence from picture naming task in Iranian Azerbaijani Turkish-Persian bilinguals [PDF]
نشریه پژوهشهای زبانشناسیAdopting a linguistic approach to the pathology of the mind on bilinguals afflicted with aphasia caused by Alzheimer's disease (AD) has given rise to a wide array of interdisciplinary research in recent years. However, bilinguals’ language impairments in
Maryam Pirzadeh +2 more
doaj +1 more source
Anticipated difficult airway during obstetric general anaesthesia: narrative literature review and management recommendations. [PDF]
, 2020 Mary Mushambi +2 more
openalex +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Prediction of Body Image Concern Based on Self-Objectification and Rumination Mediated by Self-Esteem in Women Seeking Cosmetic Surgery [PDF]
مطالعات روانشناختیGiven the increasing trend of cosmetic surgery in Iran and the role of psychological factors in this inclination, the present study aimed to investigate the prediction of body image concern based on self-objectification and rumination, with the mediating
Arefeh Abdollahi Nia +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Value Perception of the Chronotope in the Author’s Discourse (Based on the Works of Kazakh Authors)
Open Cultural StudiesThe relevance of the study is due to the increased interest of researchers in the study of the chronotope category in recent decades, and the lack of a unified approach to the analysis of the chronotope in the scientific community.
Zhiyenalina Aizhan +2 more
doaj +1 more source