Results 151 to 160 of about 2,774,651 (214)

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Cultural and ethnopharmacological uses of wildlife in the himalayan region of Azad Jammu and Kashmir, Pakistan. [PDF]

J Ethnobiol Ethnomed
Jahangeer M, Altaf M, Irshad N, Tariq M, Chowhan S, Hussain T, Narejo AH, Ali M, Muhamad M, Ashraf S, Wahab A, Abdi G.   +11 more
europepmc   +1 more source

Synergistic Additive and Bulky Cation Engineering via a Sequential Vacuum Dry‐Dipping Process for Tin Perovskite Solar Cells

Advanced Science, EarlyView.
A spin‐coating‐free sequential blade–dipping process is developed for efficient tin perovskite solar cells. Amorphous SnI2 templates are blade‐coated and vacuum‐dried, followed by a vertical dipping conversion. Enhanced by a synergistic additive matrix and bifunctional BATo cation, the resulting devices achieve a benchmark power conversion efficiency ...
Chun‐Hsiao Kuan, Xianyuan Jiang, Yun‐Sheng Shih, Chien‐Ling Ting, Po‐Kai Kang, Yue Lu, Sung‐Fu Hung, Hsin‐Lung Chen, Shiang Lan, Guan‐Ruei Chen, Jhih‐Min Lin, Chun‐Jen Su, Wei‐Ru Wu, Eric Wei‐Guang Diau   +13 more
wiley   +1 more source

Uridine diphosphate <i>N</i>-acetylglucosamine homeostasis via CgNgk1 kinase modulates chitin levels and cell-wall integrity in <i>Candida glabrata</i>. [PDF]

FEMS Microbes
Yamada R, Nakayama H, Yoshikawa S, Karita S, Umekawa M.   +4 more
europepmc   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Antibacterial microcins self-assemble to promote biofilm formation in Acinetobacter baumannii. [PDF]

Cell Rep
Telford MS, Mikesh M, Parker JK, Beckman RL, Newberry RW, Fleeman RM, Davies BW.   +6 more
europepmc   +1 more source

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Intra-strain genomic microevolution and phage resistance in <i>Pseudomonas aeruginosa</i> PAO1 laboratory isolates. [PDF]

Microbiol Spectr
Washizaki A, Pramono AK, Sakiyama A, Inaba-Hasegawa K, Mitsunaka S, Ando H.   +5 more
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Hoxa9 compensates for the absence of Hoxc9 in suppressing limb-type motor neurons in sharks. [PDF]

Zoological Lett
Yoshioka Y, Shinkai A, Mizutani M, Yu R, Kawanishi T, Kawaguchi A, Kuraku S, Tanaka M.   +7 more
europepmc   +1 more source